RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells |
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| Authors: | Joshua A Bauer Fei Ye Clayton B Marshall Brian D Lehmann Christopher S Pendleton Yu Shyr Carlos L Arteaga Jennifer A Pietenpol |
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| Affiliation: | (1) Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Preston Research Building, 2200 Pierce Avenue, 37232 Nashville, TN, USA;(2) Department of Biostatistics, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Preston Research Building, 2200 Pierce Avenue, 37232 Nashville, TN, USA;(3) Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Preston Research Building, 2200 Pierce Avenue, 37232 Nashville, TN, USA |
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| Abstract: | Introduction Paclitaxel is a widely used drug in the treatment of patients with locally advanced and metastatic breast cancer. However, only a small portion of patients have a complete response to paclitaxel-based chemotherapy, and many patients are resistant. Strategies that increase sensitivity and limit resistance to paclitaxel would be of clinical use, especially for patients with triple-negative breast cancer (TNBC). |
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