| 微小RNA-210研究进展 |
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| 引用本文： | 张露,戴琼艳,赵琳,段满林.微小RNA-210研究进展[J].国际麻醉学与复苏杂志,2014,35(11):1050-1053. |
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| 作者姓名： | 张露 戴琼艳 赵琳 段满林 |
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| 作者单位： | 1. 江苏省麻醉与镇痛应用技术重点实验室,徐州医学院江苏省麻醉学重点实验室,221004
2. 南京军区南京总医院麻醉科 |
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| 摘 要： | 背景 微小RNA（micmRNA,miRNA）是体内重要的基因水平调节物质,它能调控约1/3的人类蛋白编码基因表达.体内组织细胞缺氧后,miRNA水平发生变化,其中变化最显著的是微小RNA-210（microRNA-210,miR-210）.目的 由于miR-210易受低氧诱导,综述miR-210在低氧下的生物化学功能,并探讨其潜在的临床应用.内容 概述miR-210在线粒体代谢、血管生成、DNA修复和细胞存活等方面的作用.趋向 为miR-210相关疾病的诊疗提供参考.
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| 关 键 词： | 低氧 微小RNA 微小RNA-210 低氧诱导因子 |
Research advances of microRNA-210 |
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| Zhang Lu,Dai Qiongyan,Zhao Lin,Duan Manlin.Research advances of microRNA-210[J].international journal of anesthesiology and resuscitation,2014,35(11):1050-1053. |
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| Authors: | Zhang Lu Dai Qiongyan Zhao Lin Duan Manlin |
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| Institution: | Zhang Lu, Dai Qiongyan, Zhao Lin, Duan Manlin(The Key Laboratory of Anesthesiology, Institute of A nesthesiology of Jiangsu Province, Xuzhou Medical College, Xuzhou 221004, China) |
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| Abstract: | Background MicroRNA（miRNA） is an important regulatory factor that can regulate approximately 30% human protein-coding genes.The level of miRNA will be changed after the tissue under hypoxia,and the most significant change is of microRNA-210 （miR-210）.Objective This review discusses the emerging biochemical functions of this miRNA and explores its potential clinical applications.Content Outline the role of miR-210 in mitochondrial respiration,arrest of DNA repair,vascularbiology and angiogenesis.Trend Provide references for the diagnosis and therapy of miR-210-related disorders. |
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| Keywords: | Hypoxia MicroRNA MicroRNA-210 Hypoxia-inducible factor |
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