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UV-B Irradiation Attenuates Dermal Effects of Botulinum Toxin A: A Randomized, Double-Blind, Placebo-Controlled Study |
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| Authors: | THOMAS SYCHA MD NICOLE KOTZAILIAS MD GOTTFRIED KRANZ MD FRANZ TRAUTINGER MD PETER SCHNIDER MD AND EDUARD AUFF MD |
| Affiliation: | Department of Neurology and;Department of Dermatology, Medical University of Vienna, Vienna, Austria;;Department of Neurology, Landeskrankenhaus, Grimmenstein-Hochegg, Austria |
| Abstract: | BACKGROUND Botulinum toxin type A (BoNT/A) is frequently used for cosmetic indications and hyperhidrosis. OBJECTIVES We investigated whether UV-B irradiation alleviates the BoNT/A effect on local sudomotor activity. MATERIALS AND METHODS In a randomized, double-blinded trial, the anhidrotic areas after BoNT/A (100 mU) injection 48 hours before and 14 days after UV-B irradiation were compared in six healthy volunteers. RESULTS UV-B irradiation alleviated BoNT/A effect by approximately 30% ( p =.0017). The UV-B–evoked reduction of anhidrotic areas was constant over the observation period of 14 weeks. CONCLUSIONS When BoNT/A is applied intradermally, excessive exposure to UV-B and sunburn should be reconsidered. |
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