H-2 haplotypes carrying identical D but different L alleles |
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Authors: | F Figueroa S Tewarson P Walden Z A Nagy J Klein |
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Institution: | Max-Planck-Institut für Biologie, Abteilung Immungenetik, Tübingen, Federal Republic of Germany |
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Abstract: | The B10.SAA48 congenic line was derived by transferring the H-2 haplotype of a wild mouse onto the background of the inbred strain C57BL/10Sn (abbreviated as B10). The line carries the Dw3 allele in combination with an L allele different from that present in other Dw3 strains. One possible explanation of this finding is that crossing over occurred between the D and L loci. The determinants H-2.m64 and H-2.m65 represent an inclusion doublet in which the latter never occurs without the former. Typing of B10.W lines with Ld-specific CTLs reveals the absence of this allele in all the lines, including those carrying an allele serologically similar to Ld. |
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