急性肾功能衰竭家兔凝血功能及血液流变学的变化

目的 :探讨急性肾功能衰竭 (ARF)家兔凝血功能及血液流变学变化的临床意义。方法 :1%HgCl2 复制家兔ARF模型。通过CA150 0型血液凝固分析仪和LG R 80型锥板式粘度计测定凝血功能及血液流变学各项指标的变化。结果 :ARF组纤维蛋白原含量、血浆粘度显著高于对照组 (P <0 .0 1) ,纤维蛋白原凝结时间、红细胞比积 (HCT)显著低于对照组 (P <0 .0 1) ,其余指标无显著性差异 (P>0 .0 5)。结论 :凝血功能及血液流变学的检测 ,对于ARF的诊断、治疗及转归有重要的临床意义

Changes of Coagulation Function and Hemorheological Indexes of Acute Renal Failure in Rabbits

To inquire into changes and clinical meanings of coag ulation function and hemorheology with acute renal failure(ARF)in rabbits.Method: The ARF model of rabbit was copied by 1% HgCl 2.To meas ure the change of indexes of coagulation function and hemorheology using CA1500 type automatic programming coagulation analyzer and LG R 80 type cone plate v iscometer.Results: It showed that fibrinogen content and plasma viscosity were significantly increased than that of control group( P<0.01 ),and the fibr inogenic clotting time and hematocrit(HCT) were significantly lower compared wit h control group( P<0.01 ),and the other indexes were no signifieant difference between two groups( P>0.05 ).Conclusion: The results suggested that there is clincal meaning and provided the evidence to treatment and observation of curing effectiveness b y examing coagulation function and hemorheology with ARF.