| Cyclin D3与Ki67在非霍奇金淋巴瘤中的表达及其意义 |
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| 引用本文： | 程纯,邵晓轶,沈爱国,何松,张冬梅,刘海鸥.Cyclin D3与Ki67在非霍奇金淋巴瘤中的表达及其意义[J].中国免疫学杂志,2004,20(10):679-682,686. |
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| 作者姓名： | 程纯 邵晓轶 沈爱国 何松 张冬梅 刘海鸥 |
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| 作者单位： | 1. 南通市肿瘤医院病理科,南通,226001
2. 南通医学院微生物与免疫学教研室,南通,226001 |
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| 基金项目： | 国家自然科学基金资助项目 (3 0 3 0 0 0 99)，江苏省自然科学基金资助项目(BK2 0 0 3 0 3 5 )，江苏省高校高新技术产业发展资助项目(JH0 2 117) |
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| 摘 要： | 目的：探讨cyclinD3和Ki67在我国非霍奇金淋巴瘤(non-Hodgidn’s lymphoma，NHL）中的表达及其意义。方法：采用免疫组织化学方法检测114例IXTIL和20例反应性增生淋巴结中cyclinD3及Ki67的表达情况。结果：cyclin D3在反应性增生淋巴结(不包括生发中心)中的阳性率明显低于NHL。随着肿瘤侵袭性的增加，cyclinD3表达水平升高。Ki67在反应性增生淋巴结和NHL中的表达情况与cyclin D3一致。NHL中cyclinD3的阳性率与Ki67的表达水平呈明显正相关。结论：cyclinD3和Ki67的表达与NHL的细胞增殖活性和恶性程度密切相关，提示cyclin D3在淋巴瘤的恶性增殖过程中发挥重要作用，为淋巴瘤的诊治提供新的依据和靶点。
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| 关 键 词： | 非霍奇金淋巴瘤 Cyclin D3 Ki67 免疫组织化学 |
| 文章编号： | 1000-484X(2004)10-0679-05 |
The expression and significance of cyclin D3 and Ki67 in non-Hodgkin's lymphoma |
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| Abstract: | Objective:To investigate the expression and significance of cyclin D3 and Ki67 in non-Hodgkin's lymphoma(NHL) of China.Methods:The expression of cyclin D3 and Ki67 were detected by immunohistochemistry in 114 cases of NHL and 20 cases of reactive lymph node.Results:The level of cyclin D3 expression in reactive lymph node(except germinal center) was significantly lower than that in NHL.With the tumor aggressiveness improving,the level of cyclin D3 expression increased.The way of Ki67 expression in reactive lymph node and NHL was consistent with that of cyclin D3.Positive correlation was found between cyclin D3 and Ki67 expression.Conclusion:The level of cyclin D3 and Ki67 expression have closely related to the cell proliferation activity and the grade of malignant of NHL,which suggests that cyclin D3 play an important role in the malignant proliferation of lymphoma and provides a new foundation and target of diagnosis and therapy for lymphoma. |
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| Keywords: | Non-Hodgkin's lymphoma Cyclin D3 Ki67 Immunohistochemistry |
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