The neuroendocrine challenge paradigm in headache research |
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| Authors: | ML Gordon RB Lipton S-L Brown HM van Praag |
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| Affiliation: | Departments of Neurology and Psychiatry, Long Island Jewish Medical Center, New Hyde Park, NY, USA;;Headache Unit, Montefiore Medical Center, Bronx, NY, USA;;Departments of Neurology and Psychiatry, Albert Einstein College of Medicine, Bronx, NY, USA;;Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY, USA;;Department of Psychiatry, Academic Hospital Maastricht, Maastricht, The Netherlands |
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| Abstract: | The neuroendocrine challenge paradigm provides a "window" on central neurotransmitter function in vivo. This strategy is based on the premise that the sensitivity of certain central receptors can be inferred from the magnitude of the hormonal response to specific pharmacologic probes. For example, the serotonin (5HT) receptor agonist m-chlorophenylpiperazine (m-CPP) stimulates the release of cortisol and prolactin and induces migraine-like headaches. We have previously reported that the headache and cortisol responses to m-CPP are highly correlated, which may implicate a disturbance in central serotonergic neurotransmission in the pathogenesis of migraine. As pharmacologic probes with greater specificity for 5HT receptor subtypes become available, we may be able to elucidate these mechanisms with greater precision. The neuroendocrine challenge methodology is also applicable to the study of other neurotransmitter systems and other headache disorders. |
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| Keywords: | Hydrocortisone m-chlorophenylpiperazine migraine prolactin serotonin |
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