利心丸对小鼠缺氧耐受的影响及机理

目的研究利心丸对小鼠缺氧耐受的影响并初步探讨其机理。方法小鼠随机分生理盐水(每天20g/kg)组、心得安(每天0.16g/kg)组、利心丸高剂量(每天5g/kg)和低剂量(每天1g/kg)组,连续给药5天并于末次给药1h后测定小鼠缺氧耐受能力以及血清乙酰胆碱酯酶(T-ChE)和总抗氧化能力(T-AOC)。结果利心丸低剂量组耗氧率和心得安组均较生理盐水组显著降低(P<0.05或0.01);心得安组T-ChE活性较生理盐水组显著增高(P<0.01);心得安组和利心丸高剂量组T-AOC均较生理盐水组显著增高(P均<0.01)。结论利心丸低剂量能提高小鼠抗常压的缺氧耐受能力,可能与提高机体总抗氧化能力有关。

The effects and mechanism of Lixin Wan on the ability of anti - anoxia in mice

Objective To investigate the effects and mechanisms of Lixin Wan(LXW) on the ability of anti-anoxia in mice.Methods The mice were randomly divided into four groups: normal saline(20g/kg daily) control group,propanolol (0.16g/kg daily) group,high dose LXW(5g/kg daily) group and low dose LXW(1g/kg daily) group.The mice were given medicine for 5 days and then the oxygen consumption rate(OCR) were measured after intragastric administration for one hour at the last day and the serum activity of T-ChE and T-AOC were also detected. Results In comparison with the saline control group,the OCR in low dose LXW group and propanolol group decreased significantly(P<0.01 or 0.05).The T-ChE activity in propanolol group elevated more significantly than normal saline group (P<0.01).Compared to normal saline group,the T-AOC in propanolol group and high dose LXW group elevated more significantly(P<0.01).Conclusion Low dose LXW can improve the ability of anti-anoxia in mice at normal pressure,it maybe associated with the up-regulating ability of total antioxygen capacity.