| PLGA缓释材料在骨组织工程研究中的应用 |
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| 引用本文： | 赵锡江,齐新生.PLGA缓释材料在骨组织工程研究中的应用[J].国际生物医学工程杂志,2007,30(6):380-383. |
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| 作者姓名： | 赵锡江 齐新生 |
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| 作者单位： | 无锡市第四人民医院骨科,214062 |
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| 摘 要： | 聚乳酸聚乙醇酸共聚物(poly lactic-co-glycolic acid,PLGA)缓释材料以其具有良好的生物相容性、可控的孔径和孔隙率、体内降解时间与骨骼自身修复时间相仿、可以附载生长因子等优点,逐渐成为骨组织工程领域研究的热点。综述了PLGA缓释材料的研究进展,指出目前面临的主要问题是如何使材料更好适应骨生长以及材料中生长因子如何使用这两个方面,认为可缓释多种生长因子的PLGA缓释材料将会成为骨组织工程学研究的重点。
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| 关 键 词： | 骨 组织工程 聚乳酸聚乙醇酸共聚物 生长因子 |
| 文章编号： | 1673-4181（2007）06-0380-04 |
| 收稿时间： | 2007-06-08 |
Application of PLGA in the research of bone tissue-engineering |
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| ZHAO Xi-jiang,QI Xin-sheng.Application of PLGA in the research of bone tissue-engineering[J].International Journal of Biomedical Engineering,2007,30(6):380-383. |
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| Authors: | ZHAO Xi-jiang QI Xin-sheng |
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| Institution: | Department of Orthopaedics, Wuxi Fourth Renmin Hospital, Wuxi 214062, China |
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| Abstract: | Poly lactic-co-glycolic acid (PLGA) has been attracting increasing attention in the field of bone tissue engineering because it is a biodegradable polymer with excellent biocompatibility, controllable aperture and porous rate, and a degradation rate which is suitable for bone regeneration, and moreover a suitable carrier for the sustained release of growth factors. This article reviewed the recent research progress in PLGA as a material for controlled drug delivery with emphasis on how to make the scaffold ... |
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| Keywords: | bone tissue-engineering poly lactic-co-glycolic acid growth factors |
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