| 闭胸制备犬慢性心肌缺血和梗塞模型 |
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| 引用本文： | 孙立军 李敬帮. 闭胸制备犬慢性心肌缺血和梗塞模型[J]. 医学争鸣, 1997, 18(1): 51-53 |
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| 作者姓名： | 孙立军 李敬帮 |
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| 作者单位： | 第四军医大学西京医院放射科!西安710033，第四军医大学西京医院放射科!西安710033，第四军医大学西京医院放射科!西安710033，第四军医大学西京医院放射科!西安710033，第四军医大学西京医院放射科!西安710033，第四军医大学西京医院放射科!西安710033，第四军医大学西京医院放射科! |
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| 摘 要： | 探索建立一个新的闭胸式犬慢性心肌缺血的梗塞模型。选用１５条健康杂种犬，经右股动脉送入自制７５％和５０％缩窄器，造成左旋支或前降支狭窄。术后５－１０月，９条犬进行选择性左冠状动脉造影，左心室造影衣心肌病理学检查。
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| 关 键 词： | 心肌缺血 动物模型 |
The preparation of chronic myocardial ischemia and infarction by closed-chest technique in dogs |
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| Sun Lijun,Li Jingbang,Guo Qinglin,Yu Houjun,Zhang Yingguang,Meng Qingjiang,Wang Zhiyuan,Huang Zhilan,He Hongde. The preparation of chronic myocardial ischemia and infarction by closed-chest technique in dogs[J]. Negative, 1997, 18(1): 51-53 |
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| Authors: | Sun Lijun Li Jingbang Guo Qinglin Yu Houjun Zhang Yingguang Meng Qingjiang Wang Zhiyuan Huang Zhilan He Hongde |
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| Affiliation: | Sun Lijun,Li Jingbang,Guo Qinglin,Yu Houjun,Zhang Yingguang,Meng Qingjiang,Wang Zhiyuan,Huang Zhilan,He HongdeDepartment of Radiology,Xijing Hospital,Fourth Military Medical University,Xi'an710033 |
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| Abstract: | Objective:To develop a new closed-chest model of chronic myocardial ischemia and infarction indogs. Methods:75% and 56% stenosis of left circumflex (LCX) and left anterior descending (LAD) arteries were produced in 15 dogs using stenotic device made of polyvinyl chloride inserted through right femoral artery. Selective coronary arteriography, left cineventriculography and myocardial pathological examination were performed in 9 dogs 5-10 months after operation. Results; Occlusions or 95% stenosis of LCX and 95% stenosis of LAD were found in 5, 3 and 1 dogs respectively by coronary arteriography. Total ejection fraction of left ventricle decreased (P<0. 05) with akinesia in posterobasal and diaphragmatic segments in 5 dogs and hypokinesia in 3 dogs in LCX lesion group. Myocardial fibrosis was significant with calcification, dilatation of T tubule and regional myocardial lysis. Conclusion; This technique provides an useful model for further research on myocardial ischemia and reperfusion. |
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| Keywords: | disease model animal myocardial ischemia myocardial infarction myocardial reperfusion |
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