| 6-氨基青霉烷酸衍生物的研究Ⅰ.6-(取代丙烯酰氨)青霉烷酸的合成 |
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| 引用本文： | 段廷漢,雷兴翰. 6-氨基青霉烷酸衍生物的研究Ⅰ.6-(取代丙烯酰氨)青霉烷酸的合成[J]. 药学学报, 1965, 12(8): 516-522 |
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| 作者姓名： | 段廷漢 雷兴翰 |
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| 作者单位： | 南京药学院，化学工业部上海医药工业研究院 进修教师 |
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| 摘 要： | 本文报导了22个6-(取代丙烯酰氨)青霉烷酸化合物的合成.这类化合物系以相应的取代丙烯酸,通过混合酸酐或酰氯,在微碱性、低温下,与6APA进行缩合;再以N-乙基六氢吡啶或N,N′-二苄基乙二胺成盐纯化精制.它们的抗菌作用正在筛选中.
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| 收稿时间： | 1965-02-25 |
DERIVATIVES OF 6-AMINOPENICILLANIC ACID Ⅰ. SYNTHESIS OF 6-(SUBSTITUTED ACRYLAMIDO) PENICILLANIC ACID |
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| DWAN T''ING-HAN AND LEI HSING-HAN. DERIVATIVES OF 6-AMINOPENICILLANIC ACID Ⅰ. SYNTHESIS OF 6-(SUBSTITUTED ACRYLAMIDO) PENICILLANIC ACID[J]. Acta pharmaceutica Sinica, 1965, 12(8): 516-522 |
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| Authors: | DWAN T''ING-HAN AND LEI HSING-HAN |
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| Abstract: | Twenty-two new derivatives of 6-aminopenicillanic acid have been prepared either by the mixed carboxylic-carbonic anhydride or by the usual acyl chloride method. They were isolated and purified either as their N-ethylpiperidine or as their N, N'-dibenzyl- ethylenediamine salts. Biological evaluations of these derivatives are in progress. |
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