米非司酮治疗子宫内膜异位症疗效及对子宫内膜PCNA的影响

【目的】探讨米非司酮(RU486)治疗子宫内膜异位症的疗效及对子宫内膜增殖细胞核抗原(PCNA)的影响。【方法】观察60例患者服用RU486前后症状、体征及用药前后子宫内膜增殖细胞核抗原(PCNA)表达水平。【结果】在治疗期间所有患者均闭经;与治疗前比较治疗6个月后,总主观症状评分下降了92.4%(P<0.05),子宫内膜PCNA水平比用药前显著降低(P<0.01)。停止治疗后于4～6周恢复月经。不良反应为潮热。【结论】RU486是治疗子宫内膜异位症的有效药物,抑制子宫内膜细胞增殖为其作用机制之一。

The Effect of Mifepristone in Endometriosis and on Expression of PCNA in Endometrium

[Objective]To investigate the effect of mifepristone(Ru486) in endometriosis and on expression of PCNA in endometrium.[Methods]The symptoms, physical signs and the expression of PCNA in endometrium were analysed before and after Ru486 treatment in 60 cases.[Results]The subjective symptoms scores were decreased by 92.4% ( P <0.05) and PCNA expression in endometrium were lower ( P <0.001) after six months treatment than before treatment. All patients regained normal menstruation in 4~6 weeks after whole therapeutic course finished. The side effect of Ru486 therapy was hectic fever.[Conclusion]Ru486 is an effective drug for endometriosis, one of the mechanisms is to suppress the proliferation of endometrium.