| 柴葛清热颗粒的质量标准研究 |
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| 引用本文： | 张玲,何开勇.柴葛清热颗粒的质量标准研究[J].中国药师,2012,15(9):1238-1240. |
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| 作者姓名： | 张玲 何开勇 |
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| 作者单位： | 1. 仙桃市第一人民医院,湖北仙桃,433000
2. 湖北省食品药品检验所 |
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| 摘 要： | 目的:建立柴葛清热颗粒的质量标准。方法:用TLC法对葛根、黄芩进行定性鉴别;用HPLC法测定柴胡中柴胡皂苷a和柴胡皂苷d的含量。结果:薄层色谱图斑点清晰,阴性对照无干扰;柴胡皂苷a在0.52～10.48μg和柴胡皂苷d在0.36～7.12μg内线性关系良好,平均回收率分别为98.57%和98.73%,RSD分别为0.76%和0.75%(n=6)。结论:该方法专属性强,灵敏度高,重复性好,可用于柴葛清热颗粒的质量控制。
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| 关 键 词： | 柴葛清热颗粒 柴胡皂苷 葛根素 黄芩苷 薄层色谱法 高效液相色谱法 |
| 收稿时间： | 2012/4/25 0:00:00 |
| 修稿时间： | 2012/6/28 0:00:00 |
Quality Standard of Chaige Qingre Granules |
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| Zhang Lin and He Kaiyong.Quality Standard of Chaige Qingre Granules[J].China Pharmacist,2012,15(9):1238-1240. |
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| Authors: | Zhang Lin and He Kaiyong |
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| Institution: | 1.The First People＇s Hospital of Xiantao City,Hubei Xiantao 433000,China;2.Hubei Institute for Food and Drug Control) |
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| Abstract: | Objective： To establish the quality standard for Chaige Qingre granules.Method： Radix Puerariae lobatae and Radix Scutellariae in Chaige Qingre granules were identified by TLC.The contents of saikosaponin a and saikosaponin d were determined by HPLC.Result： The developed TLC spots were fairly clear without interference.The calibration curve of saikosaponin a and saikosaponin d was linear within the range of 0.52-10.48 μg and 0.36-7.12 μg,respectively.The average recovery was 98.57% and 98.73%,and RSD was 0.76% and 0.75%（n=6）,respectively.Conclusion： The selectivity,sensitivity and reproducibility of the method are promising,which can be used in the quality control of Chaige Qingre granules. |
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| Keywords: | Chaige Qingre granules Saikosaponin Puerarin Baicalin TLC HPLC |
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