| 妇科肿瘤表遗传学研究进展 |
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| 引用本文： | 陈凯英,金杭美.妇科肿瘤表遗传学研究进展[J].中国妇幼健康研究,2003,14(6):431-433. |
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| 作者姓名： | 陈凯英 金杭美 |
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| 作者单位： | 浙江大学医学院附属妇产科医院,浙江,杭州,310006 |
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| 摘 要： | 表遗传主要包括组蛋白乙酰化和DNA甲基化两种主要形式 ,目前认为组蛋白乙酰化和DNA低甲基化可促进基因表达 ,而组蛋白去乙酰化和DNA高甲基化可抑制基因表达。肿瘤组织中存在着基因组普遍的低甲基化和局部区域的过甲基化现象 ,DNA甲基化是肿瘤抑制基因失活的第三种机制 ,妇科肿瘤的形成与基因的表遗传明显相关
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| 关 键 词： | 表遗传 妇科肿瘤 |
| 文章编号： | 1008-2514(2003)06-431-3 |
| 修稿时间： | 2003年10月10 |
Progress in research on epigenetics in gynecological tumors |
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| CHEN Kai ying,JIN Hang mei.Progress in research on epigenetics in gynecological tumors[J].Chinese Journal of Maternal and Child Health Research,2003,14(6):431-433. |
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| Authors: | CHEN Kai ying JIN Hang mei |
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| Abstract: | Epigenetics include two main forms: DNA methylation and histon acetylation. For present, it is considered that histon acetylation and DNA hypomethylation can promote gene expression, while histon deacetylation and DNA hypermethylation can inhibite gene expression. The phenomena of universal hypomethylation of genome and region specific permethylation present in tumor tissues. DNA methylation represents the third mechanism by which antioncogenes are inactivated. Epigenetics are significantly associated with genesis of gynecological tumors. |
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| Keywords: | epigenetics gynecological tumor |
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