| 空肠弯曲菌慢性感染诱致自身免疫反应的机理初探 |
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| 引用本文： | 孙兵,马宝骊.空肠弯曲菌慢性感染诱致自身免疫反应的机理初探[J].中国免疫学杂志,1991(2). |
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| 作者姓名： | 孙兵 马宝骊 |
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| 作者单位： | 上海第二医科大学免疫学教研室，上海市免疫学研究所基础免疫1室 上海 200025，上海 200025 |
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| 摘 要： | 用空肠弯曲菌CJ—S131株感染昆明种小鼠3个月,观察到:(1)感染鼠血清中,出现高滴度的抗ds—DNA和ss—DNA抗体;(2)Con A诱导的抑制细胞功能降低和TH/Ts细胞比值增加;(3)PFC形成和LPS诱致的淋巴细胞转化作用增强:(4)DTH和Con A及PHA诱致的淋巴细胞转化作用增强。提示,CJ—S131感染小鼠使其T_S细胞功能降低,导致T_H细胞功能偏亢,B细胞功能亢进,这可能与自身免疫反应的产生有关。
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| 关 键 词： | 空肠弯曲菌 慢性感染 自身抗体 Ts细胞 自身免疫反应 |
Study on the mechanism of autoimmunity induced by CJ-S131 infection |
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| Sun Bing,Ma Baoli.Study on the mechanism of autoimmunity induced by CJ-S131 infection[J].Chinese Journal of Immunology,1991(2). |
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| Authors: | Sun Bing Ma Baoli |
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| Institution: | Sun Bing,Ma Baoli. Department of Immunology of Shanghai Second Medical University,Division I Department of Basic Immunology,Shanghai Institute of Immunology,Shanghai 200025,China |
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| Abstract: | Using Campylobacter ieiuni, strain of CJ-S131 to infect KM mice. Three months after infection, we examined the function of T and B cells in infected mice. We found that(l) there were higher, level antibodies against ds-DNA, ss-DNA.(2) ConAinduced suppressor cell activity was decreased and the ratio of Th/Ts was increased (3) The formation of PFC and lymphocyte transformation induced by LPS.PHA and ConA were increased. (4) The DTH reaction also was increased. The results mentioned above indicated that chronic infection of CJ-S131 would induce autoimmunity in KM mice.The ineffitiency of Ts cell function could be related to the hyperactivity of Th and B cells. |
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| Keywords: | Campylobacter jejuni Chronic infection Auto-ant i bodies Autoimmunity T suppressor cell |
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