卵巢囊性颗粒细胞瘤临床病理观察

目的探讨卵巢囊性颗粒细胞瘤的临床病理学特征、诊断以及相关的鉴别诊断。方法复习2例卵巢囊性颗粒细胞瘤临床资料,观察组织病理学表现、进行免疫组化染色,同时复习相关文献。结果2例女性分别为28岁和60岁,肿瘤为囊性,大小分别为12 cm×11.5 cm和6.5 cm×4 cm,囊内壁由单层和/或多层颗粒细胞构成,囊壁中可见实性片状排列的颗粒细胞。免疫组化标记inhibin,CD99,Vimentin阳性。结论卵巢囊性颗粒细胞瘤较少见,在囊内壁中的成片颗粒细胞中找到Call-exner小体或微滤泡结构是诊断的关键,免疫组化染色对诊断具有帮助。

Cystic granulosa cell tumor of the ovary:a clinicopathological observation

Objective To investigate the clinicopathologic features and relevant differential diagnosis of the cystic granulosa cell tumor of the ovary.Methods Two cases of cystic granulosa cell tumor of the ovary were analyzed with light microscopic,immunohistochemical analyses and related literature was reviewed.Results Two female patients were 28 and 60 years old respectively.Tumors appeared entirely cystic,measuring 12 cm×11.5 cm and 6.5 cm ×4 cm.The inner surface of cysts were lined by single and/or multiple layer of granulosa cells.Solid sheath of granulose cells were desmonstranted in this cystic walls.Immunohistochemically,the tumor cells were diffusely positive for inhibin,CD99 and Vimentin.Conclusions Cystic granulosa cell tumor of the ovary is a rare tumor.The key point of its diagnosis is to find Call-exner body and micro-follicular pattern in solid sheath of the cells.The immunohistochemical findings may help for diagnosis.