| 阿斯匹林与维拉帕米并用对血小板聚集和血栓形成的影响 |
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| 引用本文： | 董尔丹 石山. 阿斯匹林与维拉帕米并用对血小板聚集和血栓形成的影响[J]. 中国药理学通报, 1990, 6(6): 375-378 |
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| 作者姓名： | 董尔丹 石山 |
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| 作者单位： | 包头医学院心血管研究室，包头医学院心血管研究室 包头 014010，包头 014010 |
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| 摘 要： | ASA与Ver对ADP诱导的兔体外血小板聚集和大鼠半体内血小板聚集均有明显的抑制作用,且呈量效关系。两者合用作用增强。ASA与Ver均能明显延长电刺激大鼠颈动脉血栓的形成时间,减少胶原和肾上腺素复合诱导剂静脉注射所引起的小鼠肺血栓形成的死亡。剂量与效应相关。两者合用作用增强。
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| 关 键 词： | 阿斯匹林 维拉帕米 血小板聚集 颈动脉血栓 肺血栓 协同作用 |
EFFECTS OF THE COMBINATION OF ASPIRIN AND VERAPAMIL ON PLATELET AGGREGATION AND THROMBOGENESIS |
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| Dong Erdan,Shi Shan. EFFECTS OF THE COMBINATION OF ASPIRIN AND VERAPAMIL ON PLATELET AGGREGATION AND THROMBOGENESIS[J]. Chinese Pharmacological Bulletin, 1990, 6(6): 375-378 |
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| Authors: | Dong Erdan Shi Shan |
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| Abstract: | The effects of Verapamil ( Ver ) . Aspirin ( ASA ) and ASA+ Ver on platelet aggregation and generation of thrombosis were studied. ASA and Ver inhibited rabbit platelet aggregation in vitro and rat platelet aggregation in vivo induced by ADP, also prolonged the occlusion time of thrombosis that was induced electrically in the carotid artery of the rat, and reduced the death rate resulted from pulmonary thrombosis that was induced with inducer composed of collagen and epinephrine iv in mice. The effects of Ver and ASA were markedly increased when combined, meanwhile all showed good dose-dependant manner. |
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| Keywords: | Aspirin Verapamil Platelet aggregation Carotid artery thrombosis Pulmanary thrombosis Synergism |
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