| 可溶性Flt-1在子痫前期患者胎盘组织中的变化及意义 |
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| 引用本文： | 李怡,李东红,张春利,赵宏喜,黄亮,侯秀红,姚元庆.可溶性Flt-1在子痫前期患者胎盘组织中的变化及意义[J].中国优生与遗传杂志,2005,13(6):19-21,18. |
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| 作者姓名： | 李怡 李东红 张春利 赵宏喜 黄亮 侯秀红 姚元庆 |
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| 作者单位： | 第四军医大学唐都医院妇产科,西安,710038 |
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| 摘 要： | 目的研究可溶性血管内皮生长因子受体1(soluble fms-like tyrosine kinase receptor 1, sFlt-1)mRNA在子痫前期患者胎盘组织中的表达与定位,探讨其与子痫前期的关系.方法通过半定量RT-PCR及原位杂交方法分别检测子痫前期患者和健康孕妇胎盘组织中sFlt-1 mRNA的表达及定位.结果正常胎盘组织和子痫前期胎盘组织中均存在sFlt-1 mRNA,子痫前期胎盘组织中sFlt-1 mRNA表达明显高于正常胎盘组织(P<0.01).sFlt-1 mRNA主要分布在胎盘绒毛滋养细胞及血管内皮细胞胞浆内.结论胎盘组织中sFlt-1的高表达可能参与了子痫前期的病理生理过程.
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| 关 键 词： | 可溶性血管内皮生长因子 子痫前期 原位杂交 |
| 文章编号： | 1006-9534(2005)06-0019-04 |
Alteration and potential role of soluble fms-like tyrosine kinase receptor 1 in preeclampsia |
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| LI Yi,LI Dong-hong,ZHANG Chun-Li,et al..Alteration and potential role of soluble fms-like tyrosine kinase receptor 1 in preeclampsia[J].Chinese Journal of Birth Health & Heredity,2005,13(6):19-21,18. |
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| Authors: | LI Yi LI Dong-hong ZHANG Chun-Li |
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| Abstract: | Objective:To investigatethe expression and location of soluble fms-like tyrosine kinase receptor 1 (sFlt-1) mRNA in placenta of preeclampsia and its role in preeclampisa pathophysiology. Methods: Semi-quantitative RT-PCR was carried out to detect the level of sFlt-1 mRNA in placental tissue of 10 preeclampsia (study group) and 10 normotensive pregnancies (control group); sFlt-1 mRNA was pinpointed by in situ hybridization. Results: The sFlt-1 mRNA was expressed in both preeclampsia and normal placenta. However, its levels were significantly higher in the former than in the latter (P<0.01); sFlt-1 mRNA was located in trophocyte of placenta by in situ hybridization. Conclusion: Higher expression of sFlt-1 may be associated with the pathogenesis of preeclampsia. |
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| Keywords: | Preeclampsia sFlt-1 In situ hybridization |
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