三种不同止吐方案预防化疗所致恶心呕吐的费用-效果分析

目的：从几组化疗止吐剂中筛选一贴经济有效、便于推广应用的止吐处方。方法：采用CCT将149例非顺铂化疗病人分为A、B、C三组。A组52例，使用国产格拉司琼；B组47例，用恩丹西酮；C组50例，用胃复安 地塞米松。以止吐效果为主要指标进行多侧面观察比较。结果：止恶心、止吐有效率，A组有效率分别为92．3％-94．2％，B组为87．2％-89．3％，C组有效率分别分48．0％-68．0％。A、B、C三组的不良反应发生率分别为25．0％、36．2％、52．0％。结论：格拉司琼可作为非顺铂化疗止吐首选用药，恩丹西酮可作为非顺铂化疗止吐次选用药，胃复安 地塞米松可作为经济负担较为困难的化疗病人止吐用药。

The Cost- effectiveness Analysis of Three Groups of Antiemetic to Prevent Emesis from Chemotherapy

Objective:To search for an antiemetic recipe,which is economical, effective and easy for application, three groups of drugs were screened.Method:149 non-cisplatin chemotherapy subjects were divided into three groups by clinical controlled trail, 52 cases in A group were treated with granisetron and 47 cases in B group with ondasetron while 50 cases in C group with metoclopramide and dexamethasone. The antivomiting effect and other symptoms were invesigated.Results:The effective rate of anti-nausea and anti-vomiting was 92.3% and 94.2% for A group, 87.2% and 89.3% for B group, and 48.0% and 68.0% for C group. The side effect incidence for A, B and C group was 25.0%,36.2% and 52%.The result of cost-effectiveness was 14.69 for group A and 26.59 for groupB.Conclusions:Granisetron can be used as the first antiemetic for non-cisplatin chemotherapy, ondasetron as the second antiemetic while metoclopramide and dexamethasone for the poor patients on chemotherapy.