| 锌对免疫细胞功能影响的体外实验研究 |
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| 引用本文： | 冯建英 陈吉棣. 锌对免疫细胞功能影响的体外实验研究[J]. 营养学报, 1993, 15(3): 275-279 |
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| 作者姓名： | 冯建英 陈吉棣 |
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| 作者单位： | 北京医科大学运动医学研究所营养生化研究室，北京医科大学运动医学研究所营养生化研究室 北京 100083，北京 100083 |
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| 摘 要： | 用不同浓度含锌培养液在体外培养小鼠脾脏淋巴细胞。当锌浓度在0.12～0.5×10~(-4)mol/L时,~3H-TdR掺入淋巴细胞量明显增加;与分裂原共同培养时,锌明显促进淋巴细胞对ConA和LPS的增殖反应,其促增殖的最佳浓度为0.12×10~(-4)mol/L。锌浓度在1.0×10~(-4)mol/L以上时呈现对细胞的毒性作用。锌还促进混合淋巴细胞反应;增强胸腺细胞对IL-1的增殖反应。
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| 关 键 词： | 锌 免疫功能 |
EFFECT OF ZINC ON THE FUNCTION OF IMMUNE CELLS IN VITRO |
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| Feng Jianying,Chen Jidi. EFFECT OF ZINC ON THE FUNCTION OF IMMUNE CELLS IN VITRO[J]. Acta Nutrimenta Sinica, 1993, 15(3): 275-279 |
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| Authors: | Feng Jianying Chen Jidi |
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| Abstract: | The spleno-and thyme-lymphocytes of mice were cultured in the media with various concentrations of zinc. The results showed that zinc acted as a weak mitogen and stimulating lymphocyte proliferation at 0.12-0.5× 10-4 mol/L. It also enhanced the lymphocyte proliferation to Con A and LPS. The optimal concentration was 0.12×10-4mol/L. It enhanced the MLR of spleno-lym-phocyte and increased the responsive ability of thymocyte to IL-1. Zinc was poisonous to cells at concentrations higher than 1.0 ×10-4mol/L. |
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| Keywords: | zinc immune function |
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