Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris |
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| Authors: | Z B Tu C Konno D D Soejarto D P Waller A S Bingel R J Molyneux J A Edgar G A Cordell H H Fong |
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| Institution: | Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612. |
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| Abstract: | The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1-10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and senecionine N-oxide, suggesting that the latter two compounds were probably responsible for the effect seen with the extract. No antifertility effects were seen in MeOH extract-treated hamsters. |
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