Phorbol ester cardiotoxicity: Are ·O 2 − radicals involved? |
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| Authors: | Edwin Esser Gerriet Loschen Prof. Dr. Leopold Flohé |
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| Affiliation: | (1) Center of Research, Grünenthal GmbH, Aachen;(2) Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-3300 Braunschweig, Germany |
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| Abstract: | The effect of superoxide dismutase (SOD) on cardiotoxic effects induced by phorbol 12-myristate 13-acetate (PMA) was investigated in isolated perfused rat hearts. The negative inotropic effect, vasoconstriction, and mild bradycardia were uneffected by SOD in the perfusion medium. Perfusion of Langendorff hearts with PMA and oxidized cytochrome c ± SOD gave no evidence for a formation of ·O2–radicals in response to PMA. Cytochrome c reduction detected in the perfusate of PMA-treated Langendorff hearts is not inhibited by SOD and has thus to be attributed to ·O2–-independent myocardial reducing systems.This paper contains data from the doctoral thesis of E. Esser. |
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| Keywords: | PMA Phorbol ester Superoxide Superoxide dismutase Isolated perfused rat hearts |
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