肺复康合剂对肺纤维化大鼠血清变化的影响

目的观察肺复康合剂对肺纤维化大鼠血清的影响。方法选择Wistar大白鼠随机分为正常组、模型组、中药Ⅰ组、中药Ⅱ组、西药组，除正常组外，其余四组均复制肺纤维化动物模型；模型组用生理盐水灌胃，中药Ⅰ、Ⅱ组分别用高、低剂量肺复康合剂灌胃，西药组用强的松灌胃；各组分别检测血清相关指标。结果模型组大鼠血清透明质酸（HA）、层粘连蛋白（LN）和Ⅳ型胶原（CⅣ）显著高于正常组，各治疗组均显著低于模型组，中药Ⅰ、Ⅱ两组CIV显著低于西药组。结论肺复康合剂可抑制成纤维细胞活化和增殖，减少胶原纤维及非胶原糖蛋白的合成和分泌，阻抑肺纤维化的发展。

Effects of Feifukang Mistura on the Changes of Blood Serum in Rats with Pulmonic Fibrosis

Objective:To observe the bood serum change of Feifukang Mistura treating pulmonic fibrosis.Methods:Wistar rats were divided into normal group, model group, TCM group I, TCM group II and western medicine(WM) group.In addition to the normal group, the other four groups were reproduced animal model of pulmonic fibrosis. The model group were given normal saline gavage, The TCM group I given Feifukang Mistura(1g/ml) gavage, The TCM group II were given Feifukang Mistura (0.5g/ml) gavage,WM group were given prednisone gavage. Half of each group were taken blood to test in 28th,56th day. Results:The serum HA, LN and C IV of the model group rat were significantly higher than the normal group.The treatment groups were significantly lower than the model group.The TCM groups were significantly lower than that of WM group. Conclusion:Feifukang Mistura can inhibit the activation and proliferation of fibroblast, reduce collagen fibers and noncollagen protein synthesis and secretion, inhibit the development of pulmonary fibrosis.