Recombinant human factor VIIa in the management of amyloid-associated factor X deficiency |
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Authors: | Boggio L Green D |
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Affiliation: | Division of Hematology/Oncology, Department of Medicine, Northwestern University Medical School, Chicago, IL, USA. |
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Abstract: | Factor X deficiency is an important complication of amyloidosis. It is associated with severe bleeding that is difficult to control with plasma or prothrombin complex concentrates. Splenectomy ameliorates the factor X deficiency, but achieving satisfactory haemostasis for this operation is problematic. We report that a new clotting concentrate, recombinant factor VIIa, readily controls bleeding and makes splenectomy feasible. |
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Keywords: | amyloid factor X deficiency recombinant factor VIIa splenectomy haemostasis |
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