| 辛伐他汀抑制鼻咽癌细胞迁移 |
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| 引用本文： | 涂永生,王红艳,许继德,李建华,彭妙茹,刘筱蔼. 辛伐他汀抑制鼻咽癌细胞迁移[J]. 中国临床药理学与治疗学, 2009, 14(4): 401-404 |
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| 作者姓名： | 涂永生 王红艳 许继德 李建华 彭妙茹 刘筱蔼 |
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| 作者单位： | [1]广州医学院生理学教研室,广东广州510182 [2]广州医学院病理学教研室,广东广州510182 |
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| 基金项目： | 广东省医学科学研究基金，广州医学院科学研究项目 |
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| 摘 要： | 目的：研究辛伐他汀对鼻咽癌细胞株CNE2细胞迁移的作用。方法：用损伤修复实验和transwell实验观察辛伐他汀对鼻咽癌细胞株CNE2细胞迁移的抑制作用。结果：损伤修复实验结果显示，辛伐他汀浓度和时间依赖性地抑制鼻咽癌细胞株CNE2细胞迁移，2．5μmol／L的辛伐他汀作用24h，其迁移距离为对照组24h的50．1％。transwell实验结果表明2．5μmol／L的辛伐他汀处理24h，迁移细胞数量为对照组的69．2％。结论：辛伐他汀能浓度、时间依赖性地抑制CNE2细胞迁移。为辛伐他汀的临床研究提供有利的线索。
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| 关 键 词： | 辛伐他汀 鼻咽癌 细胞迁移 |
Simvastatin inhibits migration of nasopharyngeal carcinoma-2(CNE2)cells |
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| TIT Yong-sheng,WANG Hong-yan,XU Ji-de,LI Jian-hua,PENG Miao-ru,LIU Xiao-ai. Simvastatin inhibits migration of nasopharyngeal carcinoma-2(CNE2)cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 401-404 |
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| Authors: | TIT Yong-sheng WANG Hong-yan XU Ji-de LI Jian-hua PENG Miao-ru LIU Xiao-ai |
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| Affiliation: | 1Department of Physiology, Guangzhou Medical College, 2Department of pathology, Guangzhou 510182, Guangdong , China ) |
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| Abstract: | AIM: To study the effect of simvastatin on cells migration of nasophaiyngeal carcinoma cell line CNE2 in vitro . METHODS: The depressive effects of simvastatin on CNE2 cells migration were observed by scratch wound healing assay and transwell migration assay. RESULTS: The experimental result of scratch wound healing assay showed that simvastatin inhibited migration of nasopharyngeal carcinoma CNE2 cells in a time-and dose-dependent manner. With 2.5 μmol/L simvastatin treatment for 24 hs, the migration lenth was 50.1 % of that in control group. Transwell experimental result indicated that with 2.5 μmol/L simvastatin treatment for 24 hs, the migrating cell population was 69.2% of that in control group. CONCLUSION: Simvastatin can inhibits CNE2 cells migration in a time-and dose-dependent manner, which can provide rational clues for clinical research of simvastatin. |
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| Keywords: | simvastatin nasopharyngeal carcinoma migration |
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