舍曲林联合重复经颅磁刺激对老年2型糖尿病患者伴抑郁的疗效观察

目的 观察舍曲林联合重复经颅磁刺激(rTMS)对老年2型糖尿病伴抑郁患者的治疗效果.方法 选择2017-05—2020-08郑州大学第一附属医院老年内分泌科老年2型糖尿病伴抑郁患者120例,根据抛硬币法随机分为舍曲林联合重复经颅磁刺激组(联合组)和舍曲林单药治疗组(单药组)各60例,观察8周,联合组随访到53例,单药组...

Effect of sertraline combined with repetitive transcranial magnetic stimulation on depression in elderly patients with type 2 diabetes mellitus

Objective To investigate the therapeutic effect of sertraline combined with repetitive transcranial magnetic stimulation(rTMS)in elderly patients with type 2 diabetes mellitus and depression.Methods From May 2017 to August 2020,120 elderly patients with type 2 diabetes mellitus and depression in the First Affiliated Hospital of Zhengzhou University were randomly divided into sertraline combined with repetitive transcranial magnetic stimulation group(combined group)and sertraline monotherapy group(single drug group),60 cases in each group.After 8 weeks of observation,53 cases were followed up in combination group and 54 cases in single drug group.The effective rate of antidepressant treatment,HAMD-17 scores,MMAS-8 scores,DSMB-O scores and TESS scores were compared between the two groups.Results After treatment,the effective rate,MMAS-8 and DSMB-O scores of the two groups increased with the extension of treatment time,and the increase rate of the combined group were higher than that of the single drug group(P<0.05).The HAMD-17 scores of the two groups decreased with the extension of treatment time,and the decline rate of the combined group was higher than that of the single drug group(P<0.05).There was no significant difference in TESS scores between the two groups after treatment(P>0.05).Conclusion rTMS can enhance the antidepressant effect of sertraline in elderly patients with type 2 diabetes mellitus and depression,and increase the medication compliance and self-management of patients.