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舍曲林联合重复经颅磁刺激对老年2型糖尿病患者伴抑郁的疗效观察
引用本文:李素军,李伟芳,杨磊,李媛媛.舍曲林联合重复经颅磁刺激对老年2型糖尿病患者伴抑郁的疗效观察[J].中国实用神经疾病杂志,2021,24(3):208-213.
作者姓名:李素军  李伟芳  杨磊  李媛媛
作者单位:郑州大学第一附属医院,河南 郑州 450052
基金项目:河南省重大公益性项目[编号:HNZB(2010)N91号]。
摘    要:目的 观察舍曲林联合重复经颅磁刺激(rTMS)对老年2型糖尿病伴抑郁患者的治疗效果.方法 选择2017-05—2020-08郑州大学第一附属医院老年内分泌科老年2型糖尿病伴抑郁患者120例,根据抛硬币法随机分为舍曲林联合重复经颅磁刺激组(联合组)和舍曲林单药治疗组(单药组)各60例,观察8周,联合组随访到53例,单药组...

关 键 词:抑郁症  2型糖尿病  老年  重复经颅磁刺激  舍曲林

Effect of sertraline combined with repetitive transcranial magnetic stimulation on depression in elderly patients with type 2 diabetes mellitus
LI Sujun,LI Weifang,YANG Lei,LI Yuanyuan.Effect of sertraline combined with repetitive transcranial magnetic stimulation on depression in elderly patients with type 2 diabetes mellitus[J].Chinese Journal of Practical Neruous Diseases,2021,24(3):208-213.
Authors:LI Sujun  LI Weifang  YANG Lei  LI Yuanyuan
Institution:(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
Abstract:Objective To investigate the therapeutic effect of sertraline combined with repetitive transcranial magnetic stimulation(rTMS)in elderly patients with type 2 diabetes mellitus and depression.Methods From May 2017 to August 2020,120 elderly patients with type 2 diabetes mellitus and depression in the First Affiliated Hospital of Zhengzhou University were randomly divided into sertraline combined with repetitive transcranial magnetic stimulation group(combined group)and sertraline monotherapy group(single drug group),60 cases in each group.After 8 weeks of observation,53 cases were followed up in combination group and 54 cases in single drug group.The effective rate of antidepressant treatment,HAMD-17 scores,MMAS-8 scores,DSMB-O scores and TESS scores were compared between the two groups.Results After treatment,the effective rate,MMAS-8 and DSMB-O scores of the two groups increased with the extension of treatment time,and the increase rate of the combined group were higher than that of the single drug group(P<0.05).The HAMD-17 scores of the two groups decreased with the extension of treatment time,and the decline rate of the combined group was higher than that of the single drug group(P<0.05).There was no significant difference in TESS scores between the two groups after treatment(P>0.05).Conclusion rTMS can enhance the antidepressant effect of sertraline in elderly patients with type 2 diabetes mellitus and depression,and increase the medication compliance and self-management of patients.
Keywords:Depression  Type 2 diabetes  Elderly  Repetitive transcranial magnetic stimulation  Sertraline
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