HER2 codon 655 polymorphism is associated with advanced uterine cervical carcinoma |
| |
| Authors: | ?ukasz Kruszyna Margarita Lianeri Andrzej Roszak Pawe? P Jagodziński |
| |
| Institution: | 1. Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Germany;2. Institute of Medical Informatics and Statistics, University Hospitals Schleswig-Holstein, Campus Kiel, Germany;3. Department of Radiology and Neuroradiology, Klinikum Dortmund, Dortmund, Germany;4. Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, and Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain;5. Department of Pathology, General Pathology and Hematopathology, University Hospitals Schleswig-Holstein, Campus Kiel, Germany |
| |
| Abstract: | Objectives:It has been suggested that overexpression of HER2 in advanced cervical tumors can be considered an independent predictor of poor patient outcome.Design and methods:Employing PCR-RFLPs, we examined the distribution of HER2 Ile655Val (rs 1136201) genotypes and alleles in patients with advanced cervical cancer (n = 109) and controls (n = 220).Results:Odds ratio (OR) for patients with advanced cervical cancer with the HER2 Val/Val homozygous or Val/Ile heterozygous state was 1.778 (95% CI = 1.117–2.830, p = 0.0176). We also observed an association of the HER2 Val/Val genotype with advanced cervical cancer in the patient group OR = 3.706 (95% CI = 1.061–12.950, p = 0.0459). However, we did not find a significant association between the distribution of genotypes or alleles and cancer characteristics for the HER2 Ile655Val polymorphism.Conclusions:Our results indicate that the HER2 655Val variant may be associated with the incidence of advanced cervical cancer. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
