| 慢性阻塞性肺疾病合并肺间质纤维化患者外周血及诱导痰上清中炎性细胞因子分析及意义 |
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| 引用本文： | 石永传,周璇,徐丽,夏元旦,沈美珠,沈卫华,冒长青,肖春海,周敏. 慢性阻塞性肺疾病合并肺间质纤维化患者外周血及诱导痰上清中炎性细胞因子分析及意义[J]. 老年医学与保健, 2021, 0(2): 270-272,295 |
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| 作者姓名： | 石永传 周璇 徐丽 夏元旦 沈美珠 沈卫华 冒长青 肖春海 周敏 |
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| 作者单位： | 上海市第六人民医院金山分院药剂科;上海市第六人民医院金山分院呼吸科;上海市金山区众仁老年护理医院内科 |
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| 基金项目： | 上海市第六人民医院医疗集团科学研究课题(2019-1);上海市金山区第六周期医学重点专科建设项目(JSZK2019A04)。 |
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| 摘 要： | 目的 分析慢性阻塞性肺疾病(COPD)合并肺间质纤维化患者外周血及诱导痰上清中炎性细胞因子特点,分析其炎症特征.方法 选择2015年7月1日-2017年6月30日在上海市第六人民医院金山分院呼吸科住院的COPD合并肺间质性纤维化患者81例作为观察组,并以单纯COPD患者81例作为对照组.检测并比较2组外周血清及诱导痰上...
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| 关 键 词： | 老年 慢性阻塞性肺疾病 肺间质纤维化 细胞因子 |
Analysis and significance of inflammatory cytokines in peripheral blood and induced sputumsupernatant of patients with chronic obstructive pulmonary disease complicated with pulmonary interstitial fibrosis |
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| Shi Yongchuan,Zhou Xuan,Xu Li,Xia Yuandan,Shen Meizhu,Shen Weihua,Mao Changqing,Xiao Chunhai,Zhou Min. Analysis and significance of inflammatory cytokines in peripheral blood and induced sputumsupernatant of patients with chronic obstructive pulmonary disease complicated with pulmonary interstitial fibrosis[J]. Geriatrics & Health Care, 2021, 0(2): 270-272,295 |
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| Authors: | Shi Yongchuan Zhou Xuan Xu Li Xia Yuandan Shen Meizhu Shen Weihua Mao Changqing Xiao Chunhai Zhou Min |
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| Affiliation: | (Department of Pharmacy,Jinshan Branch of Sixth People's Hospital of Shanghai City,Shanghai,201599,P.R.China;Department of Respiratory,Jinshan Branch of Sixth People's Hospital of Shanghai City,Shanghai,201599,P.R.China;Department of Internal Medicine,Zhongren Elderly Nursing Hospital,Jinshan District,Shanghai,201501,P.R.China) |
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| Abstract: | Objective To investigate the clinical characteristics of inflammatory cytokines in peripheral blood and induced sputum supernatant of patients with chronic obstructive pulmonary disease(COPD) complicated with pulmonary interstitial fibrosis,and analyze its inflammatory characteristics.Methods 81 patients with COPD complicated with pulmonary interstitial fibrosis who were hospitalized in the Department of Respiration of Jinshan Branch from of Sixth People’s Hospital of Shanghai City July 1,2015 to June 30,2017 were selected as the observation group,and 81 patients with simple COPD were selected as the control group.The levels of inflammatory cytokines(IL-8,TNF-α,CTGF,TGF-β1 and ET-1) in the peripheral blood and induced sputum supernatant of the two groups were detected and compared.The observation group was further divided into the elderly subgroup and non-elderly subgroup.The levels of IL-8,TNF-α,CTGF,TGF-β1 and ET-1 in peripheral blood and induced sputum supernatant were compared between the two subgroups.Results The average content of CTGF in peripheral blood of observation group was higher than that of control group(P<0.05),and the average contents of CTGF,TGF-β1 and ET-1 in induced sputum supernatant of observation group was higher than those of control group(P<0.05).The average contents of CTGF and ET-1 in peripheral blood of elderly group were higher than those of non-elderly group(P<0.05),and the average contents of CTGF,TGF-1 and ET-1 in induced sputum supernatant of elderly group were higher than those of non-elderly group(P<0.05).Conclusion COPD patients with pulmonary interstitial fibrosis have unique inflammatory characteristics of pulmonary interstitial fibrosis,especially in the elderly. |
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| Keywords: | elderly chronic obstructive pulmonary disease pulmonary interstitial fibrosis cytokines |
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