Lung Scedosporiosis in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome |
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| Authors: | Siva T. Sarva Skantha K. Manjunath Amado X. Freire Heather S. Baldwin David B. Robins |
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| Affiliation: | 1. Department of Forest and Natural Resources Management, State University of New York College of Environmental Science and Forestry, 320 Bray Hall, One Forestry Drive, Syracuse, NY 13210, USA;2. Department of Chemical and Petroleum Engineering, The University of Kansas, 2150 Learned Hall, 1530 West 15th Street, Lawrence, KS 66045, USA;3. Department of Civil, Environmental and Architectural Engineering, The University of Kansas, 2150 Learned Hall, 1530 West 15th Street, Lawrence, KS 66045, USA |
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| Abstract: | A 31-year-old African American woman with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/ AIDS) (recent CD4 count of 66/mm3) presented to the emergency room with a tension pneumothorax that required an emergent chest tube placement. Computed tomography scan showed fungus balls in multiple lung cavities and surrounding infiltrates. The patient showed remarkable improvement with voriconazole suggesting aspergillosis. However, the patient was serologically negative for Aspergillus and other common fungal infections. Because of a persistent air leak, surgical intervention was needed. The histological finding was consistent with invasive mycosis, and cultures were positive for Scedosporium apiospermum. Literature review showed that, among patients with HIV/AIDS, Scedosporium can present from focal localized to systemic disease, is resistant to traditional antifungal agents, and may respond to prompt management with voriconazole. |
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