Effects of acetylsalicylic acid on serum paraoxonase activity,Ox-LDL,coenzyme Q10 and other oxidative stress markers in healthy volunteers |
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| Authors: | Sevil Kurban Idris Mehmetoglu |
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| Affiliation: | 1. Catalysis and Nanomaterials Research Laboratory, Department of Chemistry, Loyola College, Chennai-34, India;2. Materials Division, School of Advanced Sciences, Vellore Institute of Technology University, Chennai Campus, Chennai-127, India;3. Centre for Nanofibres and Nanotechnology, National University of Singapore, Singapore;1. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL 60612, United States;2. Department of Biochemistry, Molecular and Cell Science, Arkansas College of Osteopathic Medicine, Fort Smith, AK 72916, United States;3. Department of Veterans Affairs, Jesse Brown VA Medical Center, Chicago, IL 60612, United States;1. Faculty of Veterinary Medicine, Tehran University, P.O. Box 14155-6453, Tehran, Iran;2. Razi Vaccine & Serum Research Institute, Agricultural Research Education and Extension Organization, P.O. Box 31975-148, Karaj, Iran;1. Pharmacy Practice, Husson University School of Pharmacy, Bangor, ME;2. Department of Psychiatry, Maine Medical Center, Portland, ME;3. Department of Psychiatry, Tufts University School of Medicine, Boston, MA;4. Department of Neurology, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT;1. Department of Mathematical Sciences, Tezpur University, Tezpur 784 028, India;2. Department of Mathematics, Indian Institute of Technology Guwahati, Guwahati 781 039, India;3. Department of Mathematics, The George Washington University, 2115 G Street, NW, Washington, DC 20052, USA |
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| Abstract: | Objectives:The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers.Design and Methods:30 volunteers of which 17 received ASA as 100 mg/day (Group I) and 13 received ASA as 150 mg/day (Group II) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q10 (CoQ10) levels were measured before and 1 and 2 months after treatment.Results:There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group II were significantly reduced after 2 months of treatment (p < 0.05).Conclusions:Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent. |
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