|
|||||
|
|
The paraoxonase L55M and Q192R gene polymorphisms and myocardial infarction in a Tunisian population |
|
| Authors: | Amani Kallel Yousra Sediri Mohamed Hédi Sbaï Mohamed Sami Mourali Moncef Feki Monia Elasmi Samah Haj Taieb Haïfa Sanhaji Omar Souheil Rachid Mechmeche Riadh Jemaa Naziha Kaabachi |
| Institution: | 1. Research Laboratory LR99ES11, Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia;2. Department of Cardiology, Rabta University Hospital, Tunis, Tunisia;1. Universidade Federal de São Paulo (UNIFESP), Santos, SP, Brasil;2. Departamento de Ciências do Movimento Humano, Universidade Federal de São Paulo (UNIFESP), Santos, SP, Brasil;3. Departamento de Biociências, Universidade Federal de São Paulo (UNIFESP), Santos, SP, Brasil;4. Universidade Metropolitana de Santos (UNIMES), Santos, SP, Brasil;5. Departamento de Saúde, Educação e Sociedade, Universidade Federal de São Paulo (UNIFESP), Santos, SP, Brasil;1. Laboratoire d''Étude des Matériaux Optoélectronique & Polymères, Department of Physics, University of Oran 1 Ahmed Ben Bella, BP 1524 El M''Naouer, 31000, Oran, Algeria;2. Laboratoire de Physique Computationnelle des Matériaux, Department of Physics, University of Sidi-bel-Abbes Djillali Liabes, 22000, Sidi-bel-Abbes, Algeria;1. Henan Key Laboratory for Creation and Application of New Pesticides, Zhengzhou 450002, P.R. China;2. College of Plant Protection, Henan Agricultural University, Zhengzhou 450002, P.R. China;1. Department of Vascular Surgery, University of Erlangen, Erlangen, Germany;2. Department of Plastic and Hand Surgery, University of Erlangen, Erlangen, Germany;3. Department of Radiology, University of Erlangen, Erlangen, Germany |
| Abstract: | ObjectivesIn the present study, we examined a possible association between the PON1 Q192R and L55M polymorphisms and myocardial infarction (MI) in a sample of the Tunisian population.Design and methodsThree hundred and ten patients with MI and 375 controls were recruited. Paraoxonase gene polymorphisms at codon 192 and 55 were analyzed by PCR-RFLP.ResultsGenotype distributions and allele frequencies of L55M were similar among the control and MI groups. For the Q192R polymorphism patients with MI had significantly higher frequency of the RR genotype compared to controls 17.1% vs. 10.9%; OR (95% CI), 1.93 (1.24–3.02); p = 0.004]. The MI patient group showed a significantly higher frequency of the R allele compared to the controls 38% vs. 30%; χ2 = 10.74, p = 0.001]. The association between the PON1 Q192R polymorphism and MI remained significant after adjustment for other well-established cardiovascular risk factors.ConclusionsThe present study showed a significant and independent association between the PON1 Q192R polymorphism (presence of R allele) and MI in the Tunisian population. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |