Relationships between serum adiponectin,leptin concentrations and bone mineral density,and bone biochemical markers in Chinese women |
| |
| Authors: | Nan Wu Qing-Ping Wang Hui Li Xian-Ping Wu Zhen-Qiu Sun Xiang-Hang Luo |
| |
| Institution: | 1. Institute of Endocrinology & Metabolism, Xiangya Hospital of Central South University, Xiangya Road, Changsha, Hunan 410011, PR China;2. Department of Epidemiology and Statistics, School of Public Health, Central South University, Xiangya Road, Changsha, Hunan 410078, PR China;1. Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-Cho 3-18-15, Tokushima 770-8503, Japan;2. Department of Reproductive Technology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-Cho 3-18-15, Tokushima 770-8503, Japan;3. Pharmacology Research Department, Tsumura Central Research Institute, Ooaza Yoshihara 3586, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan;1. Oncology Division, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy;2. Department of Epidemiology, University of Naples “Federico II”, Naples, Italy;1. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA;2. Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA;3. Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA;4. Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA;5. Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA;1. Physiotherapy Department, Faculty of Allied Health Sciences, Bayero University, Kano, Nigeria;2. Department of Physiotherapy, University of Maiduguri Teaching Hospital, Borno-State, Nigeria;1. Divisions of Renal Medicine and Baxter Novum (CLINTEC), Karolinska Institutet, Stockholm, Sweden;2. Department of Hypertension and Nephrology, Dante Pazzanese Institute of Cardiology, São Paulo, Brazil;3. Department of Nutrition, Dante Pazzanese Institute of Cardiology, São Paulo, Brazil;4. Center for Molecular Medicine (MMK), Karolinska Institutet, Stockholm, Sweden;1. Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;2. Division of Pediatric Endocrinology, Mass General Hospital for Children and Harvard Medical School, Boston, Massachusetts;3. MGH Weight Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;4. Department of Surgery, Boston Medical Center, Boston, Massachusetts;5. Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts |
| |
| Abstract: | BackgroundAdiponectin and leptin, as the main circulating peptides secreted by adipose tissue, are potential contributors to bone metabolism. However, their association with bone mineral density (BMD) is unknown. We investigated whether these serum adipocytokines concentrations are associated with BMD and bone turnover markers.MethodsSerum adiponectin, leptin concentrations, bone turnover biochemical markers, and BMD were determined in 265 premenopausal and 336 postmenopausal Chinese women.ResultsIn postmenopausal Chinese women, the multiple linear stepwise regression analysis showed that year since menopause, lean mass, estradiol, and adiponectin, but not fat mass, leptin, were independent predictors of BMD in postmenopausal Chinese women. However, in premenopausal Chinese women, adiponectin was not the predictor of BMD. The significant positive correlations between adiponectin and bone-specific alkaline phosphatase (BAP), bone cross-linked N-telopeptides of type I collagen (NTX) were found only in postmenopausal women. Serum BAP, and NTX, but not adiponectin, decreased in response to alendronate therapy.ConclusionsAdiponectin was an independent predictor of BMD, and positively correlated with bone turnover biochemical markers in postmenopausal Chinese women, but not premenopausal women. It suggested that adiponectin may exert a negative effect on bone mass by promoting excessive bone resorption associated with bone loss. However, these effects may be mediated by menopausal status. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
