抗肿瘤靶向药品不良反应主动监测分析

目的 对抗肿瘤靶向药品不良反应(ADR)发生的规律及特点进行分析,旨在为临床合理使用提供参考.方法 通过中国医院药物警戒系统(CHPS),主动监测某三甲医院2016年5月5日至2019年2月19日的120例住院病例,使用Excel软件,分析使用抗肿瘤靶向药物致ADR的情况.结果 靶向药物致ADR共120例,患者年龄主要...

Active Monitoring of Adverse Drug Reactions Caused by Anti-tumor Targeted Drugs

Objective To analyze the occurrence and characteristics of anti-tumor targeted drug adverse reactions(ADR),so as to provide reference for rational clinical use.Methods Through the results of active monitoring of China Hospital Pharmacovigilance System(CHPS),120 inpatient medical records from A triple-A hospital’s May 5,2016 to February 19,2019 were extracted,and Excel software was used to analyze the ADR caused by anti-tumor targeted drugs.Results There were 120 cases of ADR induced by targeted drugs,the patients were mainly concentrated in 61~70 years(33.33%),and the ADR involved in the target drug was mainly in the digestive system(29.81%).the clinical manifestations were mainly gastrointestinal reactions.Conclusion The clinical use of targeted drugs should pay close attention to the adverse reactions of targeted drugs,in the course of treatment should do a good job of prevention and prognosis,pay close attention to the biochemical indicators before and after treatment,to ensure the safety of drug use.