Total-and lipid-associated sialic acid in serum and thrombocytes in patients with chronic heart failure |
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| Authors: | Canan Topçuoğlu Fatma Meriç Yılmaz Deniz Şahin Sinan Aydoğdu Gülsen Yılmaz Gülsevim Saydam Doğan Yücel |
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| Affiliation: | 1. Ankara Training and Research Hospital Department of Clinical Biochemistry, Ankara, Turkey;2. Numune Education and Research Hospital Department of Cardiology, Ankara, Turkey;1. Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People''s Republic of China;2. Department of Mental Health, Bao''an Chronic Diseases Prevent and Cure Hospital, Shenzhen, Guangdong, People''s Republic of China;3. Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Henan, People''s Republic of China;1. Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China;2. Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong Province, China;1. Department of Internal Medicine, Federal Armed Forces Central Hospital, Koblenz, Germany;2. Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany;3. Department of Medicine II, GPR Rüsselsheim, Rüsselsheim, Germany;4. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany;5. ICAN Institute for Cardiometabolism and Nutrition, Paris, France;6. Sorbonne Universités, UPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France |
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| Abstract: | ObjectivesTo investigate and discuss the total-, lipid-associated, and thrombocyte-sialic acid levels in chronic heart failure (CHF) patients.Design and methodsThirty-one chronic heart failure patients and 38 healthy controls were included in the study. Serum total sialic acid (TSA), lipid associated sialic acid (LASA), thrombocyte sialic acid (TrSA) were determined together with the traditional inflammation and prognostic markers.ResultsSerum TSA levels were significantly higher in patient group (3.08 ± 0.33 mmol/L) than control group (2.60 ± 0.17 mmol/L). Serum LASA, homocysteine, high-sensitivity CRP, brain natriuretic peptide and erythrocyte sedimentation rate were also significantly higher in patient group. TrSA levels were not significant between the groups.ConclusionTSA and LASA levels increase in CHF, independent from coronary artery disease. TrSA levels were not found to be a prognostic or valuable marker for CHF patients. Acute phase response and lipid associated portions of SA are thought to be responsible for SA rise in CHF. |
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