Impact of blood collection devices on clinical chemistry assays |
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| Authors: | Raffick AR Bowen Glen L Hortin Gyorgy Csako Oscar H Otañez Alan T Remaley |
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| Institution: | 1. Laboratory of Clinical Chemistry and Hematology, VieCuri Medical Centre, Venlo, The Netherlands;2. Emergency Department, VieCuri Medical Centre, Venlo, The Netherlands;2. Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark;3. Paracelsus Medical University, Salzburg, Austria;4. São João Hospital Center, University of Porto, Porto, Portugal;5. Faculty of Medicine, University of Porto, Porto, Portugal;6. EPI Unit, Institute of Public Health, University of Porto, Porto, Portugal;1. Department of Laboratory Medicine, Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium;2. Department of Orthopedic Surgery, Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium;1. Department of Pharmaceutical Analysis, Faculty of Pharmacy, Iuliu Ha?ieganu University of Medicine and Pharmacy, no. 6 Louis Pasteur st., 400349 Cluj-Napoca, Romania;2. Department of Functional Genomics, Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, F.-L.-Jahn-Str. 15a, 17475 Greifswald, Germany;3. Department of Proteomics and Metabolomics, MedFuture Research Center for Advanced Medicine, Iuliu Ha?ieganu University of Medicine and Pharmacy, no. 4-6 Louis Pasteur st., 400349 Cluj-Napoca, Romania;4. Department of Toxicology, Faculty of Pharmacy, Iuliu Ha?ieganu University of Medicine and Pharmacy, no. 6 Louis Pasteur st., 400349 Cluj-Napoca, Romania;5. Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, Sauerbruchstr., 17475 Greifswald, Germany;6. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany |
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| Abstract: | Blood collection devices interact with blood to alter blood composition, serum, or plasma fractions and in some cases adversely affect laboratory tests. Vascular access devices may release coating substances and exert shear forces that lyse cells. Blood-dissolving tube additives can affect blood constituent stability and analytical systems. Blood tube stoppers, stopper lubricants, tube walls, surfactants, clot activators, and separator gels may add materials, adsorb blood components, or interact with protein and cellular components. Thus, collection devices can be a major source of preanalytical error in laboratory testing. Device manufacturers, laboratory test vendors, and clinical laboratory personnel must understand these interactions as potential sources of error during preanalytical laboratory testing. Although the effects of endogenous blood substances have received attention, the effects of exogenous substances on assay results have not been well described. This review will identify sources of exogenous substances in blood specimens and propose methods to minimize their impact on clinical chemistry assays. |
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