Hyperuricemia as an Independent Risk Factor of Chronic Kidney Disease in Middle-Aged and Elderly Population |
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Authors: | Hung-Yu Chang Pei-Hsien Lee Chen-Chou Lei Yung-Chien Hsu Hsun-Hao Chang Chun-Wu Tung Chun-Liang Lin Hsueh-Fang Yang Long-Chuan Lu Ming-Chung Jong Chiu-Yueh Chen Kuei-Ying Fang Yu-Shiu Chao Ya-Hsueh Shih |
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Affiliation: | 1. Hubei Center for Disease Control and Prevention, Wuhan 430079, PR China;2. Key Laboratory of Molecular Biology of Guangdong Province, Shenzhen Center for Disease Controls and Prevention, Shenzhen 518020, PR China;3. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China;4. Wuhan Center for Disease Control and Prevention, Wuhan 430015, PR China;5. School of Public Health, Chinese University of HongKong, HongKong, PR China;1. Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, USA |
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Abstract: | IntroductionHyperuricemia in the general population remains controversial, in terms of it being considered a risk factor for chronic kidney disease (CKD). Within this context, we evaluated the effects of hyperuricemia on renal function in older Taiwanese adults.MethodsFrom January 2002 to December 2006, we conducted a community-based medical screening program involving 31,331 subjects older than 40 years. According to the National Kidney Foundation guidelines, stage 3 to 5 patients with CKD were included for analysis. Age, body mass index, systolic blood pressure, fasting plasma glucose, triglyceride, cholesterol and proteinuria were considered potential confounders.ResultsParticipants with hyperuricemia tended to have higher systolic blood pressure, sugar levels, body mass index, and cholesterol and triglyceride levels but lower estimated glomerular filtration rate (eGFR) levels; eGFR negatively correlated with serum uric acid level. By using multiple logistic regression models before and after adjusting for any confounding factors, we noted that participants with hyperuricemia had a 4.036-fold (odds ratios = 4.036) and 3.649-fold (odds ratios = 3.649) increased risk for CKD, respectively, compared with the control group. We used multiple linear regression analysis to examine the association of serum uric acid level and eGFR at different stages of CKD; significance was found only in participants with stage 3 CKD and not in participants with stages 4 or 5.ConclusionsHyperuricemia is an independent risk factor for CKD in middle-aged and elderly Taiwanese adults. Thus, an effective screening program that identifies people with hyperuricemia is warranted. |
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