The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease |
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| Authors: | Asad Vaisi-Raygani Hori Ghaneialvar Zohreh Rahimi Hamid Nomani Mohmadreza Saidi Fariborz Bahrehmand Aliakbar Vaisi-Raygani Haidar Tavilani Tayebeh Pourmotabbed |
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| Affiliation: | 1. Emergency Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China;2. State Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Diagnostic Laboratory Service, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, China;3. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China;1. Department of Chronic Non-communicable Disease Control, Wuxi Center for Disease Control and Prevention, Wuxi 214023, China;2. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China;1. Gynecologic Oncology Unit, Oncologic Reference Centre, Aviano, Italy;2. Woman''s Health Sciences Department, Polytechnic University of Marche, Ancona, Italy;3. Department of Obstetrics and Gynecology, Clinical Science Institute, L. Sacco Hospital, University of Milan, Milan, Italy;4. Gynecological, Obstetric and Pediatric Sciences Department, University of Modena and Reggio Emilia, Modena, Italy;2. Department of Nephrology, Medical University of Lublin, Poland |
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| Abstract: | ObjectiveThe role of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in early onset coronary artery disease age < 55 years (ECAD) is controversial. The aim of this study was to further evaluate the role of this ACE(I/D) gene polymorphism on the risk of premature CAD in patients from western Iran.MethodsThe ACE(I/D) genotypes were detected by PCR-RFLP in 323 individuals undergoing their first coronary angiography. Patients were placed into two groups: ECAD and late onset CAD age ≥ 55 years (LCAD).ResultsWe found a statistically significant association of the ACE D allele, as homozygous or ACE ID plus DD genotypes (ID + DD), only in the ECAD subjects OR = 1.35, p = 0.015, OR = 3.27, p = 0.014, and OR = 2.8, p = 0.013, respectively. In addition, there was a significant association after adjustment for the absence of history of diabetes, presence of normolipidemia and absence of history of blood pressure [OR 1.38, p = 0.017 and 2.35, p = 0.02]. Our results indicated that the ACE D allele is a risk factor for early onset of CAD even after correcting for conventional risk factors. The incidence of triple vessel disease was significantly higher in individuals carrying ACE(D/D) genotype in ECAD patients compared to those who carried ACE(I/I) genotype (OR 3.38; p = 0.019; 57.5% vs. 42.5%; p = 0.013).ConclusionThe presence of D allele of ACE can be important independent risk factor in the onset of CAD patients less than 55 years old in a west population of Iran. Larger collaborative studies are needed to confirm these results. |
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