Aberrant cytokines/chemokines production correlate with proteinuria in patients with overt diabetic nephropathy |
| |
| Authors: | Chia-Chao Wu Jin-Shuen Chen Kuo-Cheng Lu Chun-Chi Chen Shih-Hua Lin Pauling Chu Huey-Kang Sytwu Yuh-Feng Lin |
| |
| Affiliation: | 1. Department of Internal Medicine, Taichung Veterans General Hospital, Wanqiao Branch, Chiayi, Taiwan;2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Tungs'' Taichung MetroHarbor Hospital, Taichung, Taiwan;3. School of Medicine, National Yang Ming University, Taipei, Taiwan;4. Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan;5. Department of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;6. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;7. Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan;1. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC;2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, ROC;3. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, ROC;4. Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, ROC;5. Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC;6. Department of Internal Medicine, Cardinal Tien Hospital, Xindian, Medical School, Catholic Fu Jen University, Taipei, Taiwan, ROC;7. Superintendent, Taitung Hospital, Ministry of Health and Welfare, Taiwan, ROC;8. School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC;9. Division of Nephrology, Department of Internal Medicine, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC;1. Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;2. Department of Cardiology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China;3. Department of Nephrology, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China;4. Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA;5. Peking-Tsinghua Center for Life Sciences, Beijing, China;6. Peking University, Center for Data Science in Health and Medicine, Beijing, China;1. National Standard Laboratory of Pharmacology for Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China;2. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China;3. Jiangsu Engineering Research Center for Efficient Delivery System of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;4. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China |
| |
| Abstract: | BackgroundDiabetic nephropathy (DN) occurs in 20% to 30% of all patients with type 2 diabetes mellitus (DM) and is the most common cause of end-stage renal disease. However, the definite pathogenesis, especially the role of immune response, is still unclear.MethodsWe studied the production and expression of Th1 (IFN-γ, IL-2R), Th2 (IL-4, IL-10), proinflammatory cytokines (IL-1β, and TNF-α), and chemokines (MCP-1, and RANTES) in patients with DN. The correlation among cytokines, chemokines, and clinical parameters were examined.ResultsA patient with DN presented with longer disease duration, heavy proteinuria, and impaired renal function. Our results demonstrated increased proinflammatory cytokines, Th1 cytokines and chemokines, but not Th2 cytokines, in the plasma and urine of patients with DN as compared to patients with DM without overt nephropathy. Enhanced cytokine/chemokine activation in DN was also demonstrated by positive immunohistochemical staining of kidney tissue. We found a positive correlation between daily protein loss and plasma IFN-γ and IL-2R, and urinary MCP-1, as well as a negative correlation between creatinine clearance and plasma TNF-α and urinary MCP-1.ConclusionsThere were aberrant cytokines/chemokines production correlated with the degree of proteinuria in patient with overt DN and gross proteinuria. Inflammation may be important in the pathogenesis of DN. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
