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Effect of different calcineurin inhibitors on AOPP and TAS after kidney transplantation
Authors:Josef Zadražil  Pavel Štrebl  Karel Krejčí  Vladko Horčička  Pavel Horák  Jitka Vostálová  Adéla Zdařilová  Markéta Kajabová  Petr Schneiderka
Institution:1. Department of Internal Medicine III, University Hospital, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic;2. Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Hněvotínská 3, 775 15 Olomouc, Czech Republic;3. Department of Clinical Biochemistry, University Hospital, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic;1. Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, 117543, Singapore;2. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, 117545, Singapore;3. Protein Production Platform, School of Biological Sciences, Nanyang Technological University, 138673, Singapore;4. Public Health Research Institute, New Jersey Medical School, Rutgers University, 225 Warren Street, Newark, NJ07103, USA;1. Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany;1. JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA;2. Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, PR China;1. CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China;2. School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China;1. Instituto de Química Médica (CSIC), Juan de la Cierva 3, Madrid, 28006, Spain;2. Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad de Granada, Campus Cartuja, Granada, 18071, Spain;3. Departamento de Fisicoquímica, Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente, Facultad de Farmacia, Universidad de Granada, Campus Cartuja, Granada, 18071, Spain;4. Institut des Biomolécules Max Mousseron, IBMM-UMR 5247, Université de Montpellier, Faculté de Pharmacie, 15 Av. Charles Flahault, Montpellier, 34093, France
Abstract:ObjectivesLittle is known about the influence of calcineurin inhibitors on advanced oxidation protein products (AOPP) and total antioxidant status (TAS) after renal transplantation.Design and methodsAOPP and TAS were evaluated in transplanted patients on different calcineurin inhibitors. Thirty-five patients were treated with cyclosporine A (group A) and 33 with tacrolimus (group B).ResultsOver 6 months, the mean levels of AOPP in group A decreased from 205.9 ± 125.7 to 140.9 ± 78.9 µmol/L and TAS from 1.89 ± 0.30 to 1.75 ± 0.27 mmol/L. In group B, the mean levels of AOPP decreased from 196.5 ± 123.9 to 129.6 ± 63.8 µmol/L and TAS from 1.80 ± 0.39 to 1.78 ± 0.23 mmol/L.ConclusionNo significant differences in AOPP and TAS were found with respect to treatment. The only exception was the higher mean concentration of AOPP at month 1 in group A (p = 0.026).
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