Utility of salivary melatonin measurements in the assessment of the pineal physiology in newborn infants |
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| Authors: | Soyhan Bagci Andreas Mueller Jochen Reinsberg Axel Heep Peter Bartmann Axel R Franz |
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| Institution: | 1. University of California, Irvine Medical Center, Department of Surgery, Orange, CA;2. University of California Irvine, Biostatistics, Institute for Clinical and Translational Science, Irvine, CA;3. University of California, Irvine School of Medicine, Department of Medicine, Orange, CA;4. Pediatric Intensive Care Unit, Children''s Hospital Bambino Gesù, IRCCS, Rome, Italy;5. Children''s Hospital of Orange County, Division of Neonatology, Orange, CA;6. Children''s Hospital of Orange County, Division of Pediatric Surgery, Orange, CA;1. Département des urgences, CHU Montpellier — Univ Montpellier, Montpellier, France;2. Département d''information médicale, CHU Montpellier — Univ Montpellier, Montpellier, France;3. Département des urgences, CHU Nimes — Univ Montpellier, Montpellier, France |
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| Abstract: | SubjectsThe aim of this study was to assess whether salivary melatonin could be used as a reliable alternative to serum melatonin to study the pineal physiology in newborn infants.Design and methodsThe 95 newborn infants were allocated to four groups according to the time of sampling (09–11 am, 03–05 pm, 09–11 pm, and 03–05 am).ResultsThe median melatonin levels in serum and saliva were not significantly different between groups: median (interquartile range), 18.4 pg/mL (13.9–26.0 pg/mL) and 10.6 pg/mL (7.5–14.9 pg/mL); 13.3 pg/mL (11.5–19.0 pg/mL) and 9.1 pg/mL (7.8–14.2 pg/mL); 16.0 pg/mL (12.4–18.7 pg/mL) and 12.3 pg/mL (8.2–16.8 pg/mL); 13.0 pg/mL (8.8–27.4 pg/mL) and 11.2 pg/mL (7.7–16.6 pg/mL) for groups 1, 2, 3, and 4, respectively (p > 0.05). The results revealed a highly significant correlation between the serum and salivary melatonin levels (Pearson's correlation coefficient, r = 0.763; P < 0.001).ConclusionMelatonin levels in saliva reflect those in serum at any time of the day and like serum melatonin levels do not increase at night. |
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