Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels |
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| Authors: | Hirschfeldova Katerina Sedova Michaela Vrablik Michal Svobodova Helena Zvarova Jana Hubacek Jaroslav Ceska Richard |
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| Institution: | 1. 2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague;2. Department of Radiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague;3. Department of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague;4. 2nd Department of Surgery, Cardiovascular Surgery, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague |
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| Abstract: | ObjectivesThe aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels.Design and methodsWe analysed 743 individuals (340 men and 403 women) with high mean triglyceride and LDL-c levels. The association of five polymorphic sites (ABCA1 g.1051G>A, APOA1 g.75G>A, CETP g.629C>A, HNF1A g.102A>C, and LIPG g.584C>T), apoE isoforms and selected interactions with HDL-c levels were evaluated using linear regression models.ResultsAfter adjusting for triglycerides, sex, and BMI the only genotype with a statistically significant effect on HDL-c levels (p-value = 0.004) was the CETP promoter variant. Further, linear regression model with interactions included indicated possible interplay between APOA1 genotype and menopause (p-value = 0.002) and ABCA1 and APOE isoforms (p-value = 0.017) on HDL-c plasma concentration.ConclusionsOur study indicated that not only the CETP variant but also apoE isoforms and menopause could operate as potent modulators of HDL-c concentrations. |
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