北京地区人类免疫缺陷病毒感染者合并乙型肝炎病毒感染的流行病学特征及影响因素分析

目的:分析北京市人类免疫缺陷病毒（HIV）感染者/艾滋病（AIDS）患者合并乙型肝炎病毒（HBV）感染的流行病学特征，并探索影响合并感染的相关因素。方法:对北京地区HIV/AIDS定点治疗医院（北京协和医院、北京地坛医院、北京佑安医院）长期随访的接受抗反转录病毒治疗（ART）的13 253例HIV感染者临床资料进行回顾...

Epidemiology and influencing factors of human immunodeficiency virus and hepatitis B virus co-infected patients in Beijing

Objective To analyze the epidemiological characteristics of human immunodeficiency virus(HIV)and hepatitis B virus(HBV)co-infected patients in Beijing and investigate the associated factors.Methods The clinical data of patients with HIV infection who were treated in HIV/AIDS designated hospitals(Peking Union Medical College Hospital,Beijing Ditan Hospital and Beijing Youan Hospital)were retrospectively analyzed.Results A total of 11572 patients were finally included in the study,among whom 532 patients(4.6%)were co-infected with HIV and HBV.Most of the co-infected patients were young male adults(28~48 years old),accounting for 85.9%.The main transmission route was homosexual behavior(74.8%).There were 87.4%co-infected patients treated with two anti-HBV drugs,including lamivudine(3TC)and tenofovir(TDF).From 2013 to 2018,the annual prevalence of HIV and HBV co-infection decreased gradually,with the rate of 6.37%,4.55%,3.92%,4.68%,4.24%and 2.74%,respectively.In our study,The main influencing factors of HIV and HBV co-infection were age older than 28 years old versus<28 years old(OR=2.807,95%CI 1.241-6.345)and marriage status(married versus unmarried,OR=1.259,95%CI 1.004-1.579).Conclusions The proportion of HBV infection in HIV-infected patients is 4.60%(532)in our cohort.From 2013 to 2018,the prevalence of HIV and HBV co-infection in Beijing shows a decreasing trend.The risk of co-infection is higher in married young adults(28~48 years old).