Heart-type fatty acid binding protein is an early marker of myocardial damage after radiofrequency catheter ablation |
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| Authors: | Daniela Giannessi Marcello Piacenti Maristella Maltinti Andrea Rossi Pietro Di Cecco Umberto Startari Manuela Cabiati Luca Panchetti Silvia Del Ry Maria-Aurora Morales |
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| Affiliation: | 1. Institute of Hematology and Medical Oncology “L e A Seràgnoli”, Policlinico “Sant’Orsola-Malpighi”, University of Bologna, Bologna;2. Department of Cellular Biotechnology and Hematology, “La Sapienza” University, Rome;3. Division of Hematology, “Federico II” University, Naples;4. Department of Nuclear Medicine, Policlinico “Sant’Orsola-Malpighi”, University of Bologna, Bologna;5. Department of Radiological Sciences, “La Sapienza” University, Rome, Italy;1. Division of Cardiology, University of Tor Vergata, Rome, Italy;2. Division of Cardiology, Istituto Clinico Sant''Ambrogio, Milan, Italy;3. Division of Cardiology, Clinica Humanitas Gavazzeni, Bergamo, Italy;4. Divisione di Cardiologia, Ospedale S. Salvatore, Pesaro, Italy;5. Cardiovascular Intervention Service, Policlinico S. Donato, San Donato Milanese, Italy;6. Jagiellonian University, Dept. of Cardiac & Vascular Diseases, John Paul II Hospital, Krakow, Poland;7. Divisione di Cardiologia, Università degli Studi di Napoli Federico II, Naples, Italy;8. Division of Cardiology, Villa Maria Cecilia Hospital, Cotignola, Italy;9. Division of Vascular Surgery, Università Biccocca, Azienda Ospedaliera San Gerardo, Monza, Italy;10. Krakow Cardiovascular Research Institute, Krakow, Poland;11. Division of Pathology, Tor Vergata University, Rome, Italy;12. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy |
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| Abstract: | ObjectivesRadiofrequency (RF) ablation of arrhythmias induces myocardial damage and release of biomarkers. This study aimed to assess the kinetics of heart-type fatty acid-binding protein (h-FABP), a cytosolic protein released after myocardial injury incurred by both atrial and ventricular RF ablation, compared to other markers of myocardial injury.Design and methodsh-FABP, cTnI, CK-MBmass and myoglobin were evaluated in 30 patients with atrial or ventricular tachyarrhythmias before, immediately after and at 3, 6 and 24 h after the procedure.Resultsh-FABP increased immediately after the procedure in all subjects (6.6 ± 1.2 μg/L vs 2.7 ± 0.3, p < 0.001) but increased significantly only in ventricular ablations. The peak of h-FABP significantly correlates with the values of time for mean power of RF application in both the entire patient cohort and in ventricular ablations.Conclusionsh-FABP may be an early parameter for monitoring RF-induced lesions and the site of ablation was relevant for biomarker increase. |
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