High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults |
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Authors: | Iris HS Chan Dennis LY Lee Osan YM Ho Eddy WY Wong Yvonne YO Lam Nelson LS Tang Michael HM Chan Victor J Abdullah Chun K Wong Christopher WK Lam |
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Institution: | 1. Department of Biological Sciences, College of Biological Science and Biotechnology, Cancer and Metabolism Institute, Konkuk University, Seoul 143-701, Republic of Korea;2. Department of Applied Chemistry, Dongduk Women''s University, Seoul 136-714, Republic of Korea;3. Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea;1. Institute of Basic Biological Problems, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia;2. Lomonosov Moscow State University, Belozersky Institute of Physical–Chemical Biology, Moscow 119991, Russia |
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Abstract: | BackgroundEarly growth response-1 (Egr-1) is expressed in human airways and its polymorphisms have been associated with total IgE and atopy in asthmatic patients. We investigated the effects of Chinese-tagging single nucleotide polymorphism (SNP) of Egr-1 and its mRNA expression on allergic rhinitis (AR) traits.MethodsAmong 214 Chinese AR adults and 259 controls, tag SNP ?4071 A → G was genotyped and mRNA expression in peripheral blood was quantified by real-time PCR.ResultsEgr-1 mRNA expression was significantly higher in patients than controls (median of 0.23 vs 0.15 fold GAPDH expression; p < 0.001). Its expression was not associated with ? 4071 polymorphism. However, significant correlations were found between ? 4071 A → G with increased plasma total IgE (p = 0.028) and atopy (p = 0.030) in patients. Logistic regression confirmed the association (p = 0.034) with age and gender adjusted. Patients homozygous for the A allele had a 2.3-fold and 1.9-fold risks, respectively of having increased plasma total IgE and atopy than those G allele carriers.ConclusionsWe showed high levels of Egr-1 mRNA expression and demonstrated a significant association of polymorphism with increased plasma total IgE and atopy in AR patients. It may be useful to explore the pharmacogenetics of Egr-1 inhibitors. |
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