Association of serum carotenoids with high molecular weight adiponectin and inflammation markers among Japanese subjects |
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| Authors: | Koji Suzuki Takashi Inoue Shuji Hashimoto Junichi Ochiai Yasuhiro Kusuhara Yoshinori Ito Nobuyuki Hamajima |
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| Institution: | 1. General Chemical State Laboratory of Greece, 16 An. Tsocha Str., 11521, Athens, Greece;2. Cardiology Department, General Hospital of Karditsa, Terma Tavropou, Karditsa, Greece;3. Doping Control Laboratory of Athens, Olympic Athletic Centre of Athens, Kiffisias 37, 151 23, Maroussi, Greece;4. Clinic II for Nephrology and Endocrinology, Department for Internal Medicine, Alfrief Krupp Hospital, Alfried Krupp Str.49, 45131 Essen, Germany;5. Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece;6. ORTHOBIOTIKI Prevention and Anti-aging, Private Practice, 3-5 Sorou St., 15125, Athens, Greece;7. Second Cardiology Department, Amalia Fleming General Hospital, 14 25th Martiou Str., 15127, Athens, Greece;8. Harvard School of Public Health, Boston, MA, USA |
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| Abstract: | BackgroundSeveral studies have reported that serum concentrations of carotenoids and adiponectin are inversely associated with the risk for cardiovascular disease (CVD). However, no studies have investigated the association between serum concentrations of adiponectin and carotenoids in the general population.MethodsWe investigated cross-sectionally whether serum carotenoids are associated with serum high molecular weight (HMW) adiponectin and some inflammatory markers in 437 Japanese subjects (116 men and 321 women) who attended a health examination.ResultsIn multiple linear regression analysis adjusted for confounding factors, serum β-carotene concentrations were significantly associated with serum HMW adiponectin concentrations in both sexes (standardized β coefficient = 0.197, p = 0.036 for men; standardized β coefficient = 0.146, p = 0.012 for women). Serum α-carotene and β-carotene concentrations were significantly associated with serum C-reactive protein (CRP) concentrations in men. In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Additional adjustment for serum concentrations of IL-6 or CRP did not significantly affect the association between carotenoids and HMW adiponectin in non-smoking men as well as in women.ConclusionSerum β-carotene concentrations were positively associated with serum HMW adiponectin concentrations even after adjustment for possible confounding factors including inflammatory markers. |
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