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Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population |
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| Authors: | Yousra Sediri Amani Kallel Samir Ben Ali Souheil Omar Mohamed Sami Mourali Monia Elasmi Sameh Haj Taieb Haïfa Sanhaji Moncef Feki Rachid Mechmeche Riadh Jemaa Naziha Kaabachi |
| Affiliation: | 1. Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;2. Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi''an 710032, China;3. Department of Health Examination, Wuhan Iron and Steel Company (WISCO) General Hospital, Wuhan 430080, China;4. Department of Endocrinology, Wuhan Iron and Steel Company (WISCO) General Hospital, Wuhan 430080, China |
| Abstract: | ObjectivesThe aim of this study was to investigate the association between rs2781666 G/T polymorphism of arginase I (ARG I) gene and myocardial infarction (MI) in the Tunisian male population.Design and methodsThree hundred eighteen patients with MI and 282 controls were recruited. The rs2781666 G/T polymorphism of ARG I was determined by PCR-RFLP analysis.ResultsPatients had significantly higher frequency of TT genotype compared to controls (10.4% vs. 6.7%; p < 0.001). The MI patients showed higher frequency of T allele compared to the controls [0.33 vs. 0.22; OR (95% CI), 1.79 (1.37–2.34), p < 0.001]. The association between rs2781666 G/T polymorphism of ARG I gene and MI remained significant after adjustment for other well-established risk factors.ConclusionA significant association between rs2781666 G/T polymorphism of ARG I gene and MI was found in the Tunisian male population. |
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