Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans |
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| Authors: | Hye-Ja Lee In kyoung Kim Jae Heon Kang Younjhin Ahn Bok-Ghee Han Jong-Young Lee Jihyun Song |
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| Institution: | 1. Division of Metabolic Disease, Center for Biomedical Sciences, National Institute of Health, 194 Tongillo, Eunpyung-gu, Seoul, 122-701, Republic of Korea;2. Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Republic of Korea;3. Department of Family Medicine, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, 100-032, Korea Seoul, Republic of Korea;4. Center for Genome Science, National Institute of Health, Seoul, Republic of Korea;1. Dpt. Medical-Surgical Therapeutics, Medical School, University of Extremadura, Badajoz, Spain;2. Eating Disorders Unit, Institute of Mental Disorders, Health Service of Extremadura, Badajoz, Spain;3. Genomics Group, Fundación Investigación Hospital General Universitario de Valencia, Valencia, Spain;1. Center for Cohort Studies, Total Healthcare Screening Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea;2. Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea;8. Department of Family Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea;13. Department of Radiology, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea;9. Division of Medical Nutrition, Total Healthcare Screening Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea;3. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea;4. Departments of Epidemiology and Medicine, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;5. Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, South Korea;6. Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, National Institute of Health, Chungbuk, South Korea;7. Department of Food and Nutrition, Sookmyung Women''s University, Seoul, South Korea;10. Department of Social and Preventive Medicine, Julius Centre University of Malaya, University of Malaya Faculty of Medicine, Kuala Lumpur, Malaysia;11. National Center for Epidemiology, Carlos III Institute of Health and Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain;12. Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland;1. Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea;2. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea;3. Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Republic of Korea;1. Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan;2. Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan;3. Department of CKD Initiatives, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan;4. Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan;5. Program in Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673, Japan;6. Safety & Health Promotion Division, Toyota Motor Corporation, 1-1 Ipponmatsu, Iwakura-cho, Toyota 444-2225 Japan;7. R & D management Division, Toyota Motor Corporation, 1 Toyota-cho, Toyota 471-8572, Japan;8. Innovative Research Center for Preventative Medical Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan;1. Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, South Korea;2. National Cancer Control Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, South Korea;3. National Cancer Center Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, South Korea;4. National Cancer Center Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, South Korea;5. Department of Surgery, Keimyung University School of Medicine, Daegu, South Korea |
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| Abstract: | BackgroundAssociations with FTO (fat mass and obesity associated) gene variants and BMI have been reported in western adult populations. To widen the ethnic and age coverage of the FTO studies, we investigated the effects of FTO gene variants on being overweight and related phenotypes in Korean children and adult with a consideration of lifestyle factors.MethodsWe genotyped 711 children for 2 FTO SNPs (rs9939973 and rs9939609), analyzed lifestyle factors, and investigated the potential involvement of FTO variants in being overweight comparing with 8842 adults in the KSNP database.ResultsWith a strong association between FTO gene variants and BMI levels, we further identified an association between rs9939973 or rs9939609 and being overweight both children (P = 0.025, OR = 1.47, 95% CI = 1.05–2.06; P = 0.023, OR = 1.53, 95% CI = 1.06–2.22) and adults (P = 0.018, OR = 1.10, 95% CI = 1.02–1.19; P = 0.001, OR = 1.16, 95% CI = 1.06–1.27). Significant association was observed between rs9939609 and dietary fat intake in children (P = 0.008) but not in adults. In low physical activity subgroup of children, rs9939609 A allele carriers had a higher BMI than TT carriers (P = 0.0147). A significant interaction effect of rs9939609 on BMI across 3 levels of adult physical activity was found.ConclusionsFTO variant rs9939609 is an overweight susceptibility gene in Koreans. By low physical activity, A allele greatly influenced greater BMI. |
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