| 肠道菌群在自身免疫性疾病中的研究进展 |
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| 引用本文： | 郭风宜,杨潇,高天舒. 肠道菌群在自身免疫性疾病中的研究进展[J]. 国际免疫学杂志, 2021, 44(1): 91-96 |
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| 作者姓名： | 郭风宜 杨潇 高天舒 |
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| 作者单位： | 辽宁中医药大学研究生学院，沈阳 110847;辽宁中医药大学附属第二医院内分泌科，沈阳 110034;辽宁中医药大学附属医院内分泌科，沈阳 110032 |
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| 基金项目： | 国家自然科学基金(81503474,81874441);辽宁省科技厅自然基金项目(2019-MS-207);辽宁省教育厅项目(L201923);辽宁中医药大学中医脏象理论及应用国家教育部重点实验室项目(zyzx1804)。 |
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| 摘 要： | 自身免疫性疾病(autoimmune disease，AID)通过自身产生抗体，导致免疫耐受失衡，而引起的一系列慢性炎症反应，甚至对机体组织造成损伤。目前AID发病率逐渐升高，而其确切的发病机制尚不明确。肠道菌群作为人体最大的"免疫器官"，参与机体代谢，形成肠粘膜屏障，维持免疫功能正常。随着对人体肠道菌群研究的深入，越...
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| 关 键 词： | 肠道菌群 自身免疫性疾病 免疫反应 |
Research progress of gut microbiota in autoimmune diseases |
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| Guo Fengyi,Yang Xiao,Gao Tianshu. Research progress of gut microbiota in autoimmune diseases[J]. International Journal of Immunology, 2021, 44(1): 91-96 |
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| Authors: | Guo Fengyi Yang Xiao Gao Tianshu |
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| Affiliation: | (Graduate School,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Department of Endocrinology,the Second Affiliated Hospital,Shenyang 110034,China;Department of Endocrinology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China) |
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| Abstract: | Autoimmune diseases(AID)cause a series of chronic inflammatory reactions by the production of antibodies,leading to imbalance of immune tolerance,and even damage the body tissues.The incidence of AID has been increasing in recent year,but the exact pathogenesis is unclear.As the largest"immune organ"of human body,gut microbiota participates in the organic metabolism,forming intestinal mucosal barrier and maintaining normal immune function.With the further research on gut microbiota,more and more research results show that gut microbiota plays an important role in the process of autoimmune response,which may be a new therapeutic target for AID.In this paper,the gut microbiota and its research progress in AID were briefly summarized. |
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| Keywords: | Gut microbiota Autoimmune disease Immune response |
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