Association of glutathione S-transferase M1 and T1 gene polymorphisms and oxidative stress markers in preterm labor |
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| Authors: | M.D. Mustafa Rahul Pathak Tanzeel Ahmed Rafat S. Ahmed A.K. Tripathi Kiran Guleria B.D. Banerjee |
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| Affiliation: | 1. Department of Molecular Physiology, The Molecular Medicine Research Group, School of Medicine, Western Sydney University, Campbelltown, NSW 2150, Australia;2. Department of High Risk Obstetrics, RPA Women and Babies, Royal Prince Alfred Hospital, University of Sydney, Sydney, SW 2050, Australia;3. Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada;4. Faculty of Mathematics and Science Brock University, St. Catharines, ON L2S 3A1, Canada;1. Department of Reproductive Medicine and Infertility, Ankara Etlik Zubeyde Han?m Women’s Health Training and Research Hospital, Ankara, Turkey;2. Department of Reproductive Medicine and Infertility, Istanbul Zeynep Kamil Women’s Health Training and Research Hospital, Istanbul, Turkey;1. National Institute for Research and Development of Isotopic and Molecular Technologies, Donat 67-103, 400293 Cluj-Napoca, Romania;2. Iuliu Ha?ieganu University of Medicine and Pharmacy Cluj-Napoca, Babe? 8, 400012 Cluj-Napoca, Romania |
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| Abstract: | ObjectiveOxidative stress and related gene polymorphism may be associated with the etiology of preterm labor (PTL). The present study was designed to investigate association of GSTM1 and GSTT1 gene polymorphisms with PTL and their relationship with oxidative stress markers.Design and methodsSixty cases of PTL and sixty three subjects of full term labor (FTL) were included in the study. Multiplex PCR was performed for GSTM1 and GSTT1 genes polymorphism and oxidative stress markers were analyzed.ResultMDA and 8-OHdG levels were increased, while GSH was decreased in PTL than FTL subjects. Frequency of GSTM1?/GSTT1?(null) was significantly higher in PTL in comparison to FTL (p = 0.028, OR = 3.4). Subjects with GSTM1?/GSTT1+, GSTM1+/GSTT1?, GSTM1?/GSTT1? have significant differences of oxidative stress markers as compared to GSTM1+/GSTT1+ genotype.ConclusionGSTM1?/GSTT1? (null) genotype may be one of the associated genetic factor for the increased risk of PTL. |
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