The prevalence of metabolic syndrome is increased in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis |
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Authors: | Atas Dilek Barutcu Atas Halil ?zgi Tuba Nur Velioglu Arzu Arikan Hakki Oner Fatma Alibaz Direskeneli Haner Tuglular Serhan Asicioglu Ebru |
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Institution: | 1.School of Medicine, Department of Internal Medicine, Division of Nephrology, Marmara University, Istanbul, Turkey ;2.School of Medicine, Department of Cardiology, Marmara University, Istanbul, Turkey ;3.School of Medicine, Department of Internal Medicine, Marmara University, Istanbul, Turkey ;4.School of Medicine, Department of Internal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey ;5.Pendik Teaching and Training Hospital, Marmara University, Fevzi Cakmak Mah. MuhsinYazicioglu Cad. No: 10 Ust Kaynarca-Pendik, Istanbul, Turkey ; |
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Abstract: | Purpose Cardiovascular disease is one of the major causes of mortality in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Metabolic syndrome (MetS) is associated with increased cardiovascular risk in the normal population. However, MetS in AAV has not been adequately investigated. We aimed to determine MetS prevalence and associated factors in AAV patients. MethodsThirty-seven AAV patients and 42 healthy controls were enrolled. MetS was determined by International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria. The relationship between clinical features of AAV and MetS was also investigated. ResultsMetS was significantly higher in AAV patients than controls by NCEP-ATPIII (51.4% vs. 26.2%, p 0.022) and IDF (62.2% vs. 35.7%, p 0.020). When AAV patients with MetS were compared to those without, there were significant differences in age, CRP, GFR and NT-pro-BNP. Age 58 (13) vs. 50 (8) years p: 0.028], CRP 4.0 (3.6) vs. 3.2 (1.0) mg/l, p 0.021] and NT-pro-BNP 173.5 (343.7) vs. 106.0 (103.0) pg/ml, p 0.013] were significantly higher in AAV patients with MetS than those without; GFR was significantly lower 38 (46) vs. 83 (51) ml/min/1.73 m2, p 0.004]. ROC curve analysis showed NT-pro-BNP?>?58.0 ng/ml predicted MetS with 87.1% sensitivity and 46.7% specificity (Area under curve: 0.71, CI 0.536–0.902, p 0.041). Multivariate analysis revealed age OR (95% CI): 1.180 (1.010–1.370), p 0.039] and NT-pro-BNP?>?58 pg/ml OR (95% CI): 5.5 (1.02–30.1) p 0.047] were independent predictors of MetS in AAV patients. ConclusionMetS is significantly higher in AAV patients than controls and is associated with age and NT-pro-BNP. Screening and treating MetS may improve prognosis in AAV patients. |
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